Constitutive activation of the ETS-1-miR-222 circuitry in metastatic melanoma

MicroRNAs-221 and -222 are highly upregulated in several solid tumors, including melanomas. We demonstrate that the proto-oncogene ETS-1, involved in the pathogenesis of cancers of different origin, is a transcriptional regulator of miR-222 by direct binding to its promoter region. Differently from...

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Detalles Bibliográficos
Autores principales: Mattia, Gianfranco, Errico, M Cristina, Felicetti, Federica, Petrini, Marina, Bottero, Lisabianca, Tomasello, Luisa, Romania, Paolo, Boe, Alessandra, Segnalini, Patrizia, Di Virgilio, Antonio, Colombo, Mario P, Carè, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Signaling & Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272348/
https://www.ncbi.nlm.nih.gov/pubmed/21711453
http://dx.doi.org/10.1111/j.1755-148X.2011.00881.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272348/
https://www.ncbi.nlm.nih.gov/pubmed/21711453
http://dx.doi.org/10.1111/j.1755-148X.2011.00881.x

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