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Rising adiposity curbing decline in the incidence of myocardial infarction: 20-year follow-up of British men and women in the Whitehall II cohort

AIMS: To estimate the contribution of risk factor trends to 20-year declines in myocardial infarction (MI) incidence in British men and women. METHODS AND RESULTS: From 1985 to 2004, 6379 men and 3074 women in the Whitehall II cohort were followed for incident MI and risk factor trends. Over 20 year...

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Autores principales: Hardoon, Sarah L., Morris, Richard W., Whincup, Peter H., Shipley, Martin J., Britton, Annie R., Masset, Gabriel, Stringhini, Silvia, Sabia, Séverine, Kivimaki, Mika, Singh-Manoux, Archana, Brunner, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272419/
https://www.ncbi.nlm.nih.gov/pubmed/21653562
http://dx.doi.org/10.1093/eurheartj/ehr142
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author Hardoon, Sarah L.
Morris, Richard W.
Whincup, Peter H.
Shipley, Martin J.
Britton, Annie R.
Masset, Gabriel
Stringhini, Silvia
Sabia, Séverine
Kivimaki, Mika
Singh-Manoux, Archana
Brunner, Eric J.
author_facet Hardoon, Sarah L.
Morris, Richard W.
Whincup, Peter H.
Shipley, Martin J.
Britton, Annie R.
Masset, Gabriel
Stringhini, Silvia
Sabia, Séverine
Kivimaki, Mika
Singh-Manoux, Archana
Brunner, Eric J.
author_sort Hardoon, Sarah L.
collection PubMed
description AIMS: To estimate the contribution of risk factor trends to 20-year declines in myocardial infarction (MI) incidence in British men and women. METHODS AND RESULTS: From 1985 to 2004, 6379 men and 3074 women in the Whitehall II cohort were followed for incident MI and risk factor trends. Over 20 years, the age–sex-adjusted hazard of MI fell by 74% (95% confidence interval 48–87%), corresponding to an average annual decline of 6.5% (3.2–9.7%). Thirty-four per cent (20–76%) of the decline in MI hazard could be statistically explained by declining non-HDL cholesterol levels, followed by increased HDL cholesterol (17%, 10–32%), reduced systolic blood pressure (13%, 7–24%), and reduced cigarette smoking prevalence (6%, 2–14%). Increased fruit and vegetable consumption made a non-significant contribution of 7% (−1–20%). In combination, these five risk factors explained 56% (34–112%). Rising body mass index (BMI) was counterproductive, reducing the scale of the decline by 11% (5–23%) in isolation. The MI decline and the impact of the risk factors appeared similar for men and women. CONCLUSION: In men and women, over half of the decline in MI risk could be accounted for by favourable risk factor time trends. The adverse role of BMI emphasizes the importance of addressing the rising population BMI.
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spelling pubmed-32724192012-02-15 Rising adiposity curbing decline in the incidence of myocardial infarction: 20-year follow-up of British men and women in the Whitehall II cohort Hardoon, Sarah L. Morris, Richard W. Whincup, Peter H. Shipley, Martin J. Britton, Annie R. Masset, Gabriel Stringhini, Silvia Sabia, Séverine Kivimaki, Mika Singh-Manoux, Archana Brunner, Eric J. Eur Heart J Clinical Research AIMS: To estimate the contribution of risk factor trends to 20-year declines in myocardial infarction (MI) incidence in British men and women. METHODS AND RESULTS: From 1985 to 2004, 6379 men and 3074 women in the Whitehall II cohort were followed for incident MI and risk factor trends. Over 20 years, the age–sex-adjusted hazard of MI fell by 74% (95% confidence interval 48–87%), corresponding to an average annual decline of 6.5% (3.2–9.7%). Thirty-four per cent (20–76%) of the decline in MI hazard could be statistically explained by declining non-HDL cholesterol levels, followed by increased HDL cholesterol (17%, 10–32%), reduced systolic blood pressure (13%, 7–24%), and reduced cigarette smoking prevalence (6%, 2–14%). Increased fruit and vegetable consumption made a non-significant contribution of 7% (−1–20%). In combination, these five risk factors explained 56% (34–112%). Rising body mass index (BMI) was counterproductive, reducing the scale of the decline by 11% (5–23%) in isolation. The MI decline and the impact of the risk factors appeared similar for men and women. CONCLUSION: In men and women, over half of the decline in MI risk could be accounted for by favourable risk factor time trends. The adverse role of BMI emphasizes the importance of addressing the rising population BMI. Oxford University Press 2012-02 2011-06-08 /pmc/articles/PMC3272419/ /pubmed/21653562 http://dx.doi.org/10.1093/eurheartj/ehr142 Text en Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011. For permissions please email: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/2.0/uk/ The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Clinical Research
Hardoon, Sarah L.
Morris, Richard W.
Whincup, Peter H.
Shipley, Martin J.
Britton, Annie R.
Masset, Gabriel
Stringhini, Silvia
Sabia, Séverine
Kivimaki, Mika
Singh-Manoux, Archana
Brunner, Eric J.
Rising adiposity curbing decline in the incidence of myocardial infarction: 20-year follow-up of British men and women in the Whitehall II cohort
title Rising adiposity curbing decline in the incidence of myocardial infarction: 20-year follow-up of British men and women in the Whitehall II cohort
title_full Rising adiposity curbing decline in the incidence of myocardial infarction: 20-year follow-up of British men and women in the Whitehall II cohort
title_fullStr Rising adiposity curbing decline in the incidence of myocardial infarction: 20-year follow-up of British men and women in the Whitehall II cohort
title_full_unstemmed Rising adiposity curbing decline in the incidence of myocardial infarction: 20-year follow-up of British men and women in the Whitehall II cohort
title_short Rising adiposity curbing decline in the incidence of myocardial infarction: 20-year follow-up of British men and women in the Whitehall II cohort
title_sort rising adiposity curbing decline in the incidence of myocardial infarction: 20-year follow-up of british men and women in the whitehall ii cohort
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272419/
https://www.ncbi.nlm.nih.gov/pubmed/21653562
http://dx.doi.org/10.1093/eurheartj/ehr142
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