Structure of HDAC3 bound to corepressor and inositol tetraphosphate

Histone deacetylase enzymes (HDACs) are emerging cancer drug targets. They regulate gene expression by removing acetyl groups from lysine residues in histone tails resulting in chromatin condensation. The enzymatic activity of most class I HDACs requires recruitment to corepressor complexes. We repo...

Descripción completa

Detalles Bibliográficos
Autores principales: Watson, Peter J., Fairall, Louise, Santos, Guilherme M., Schwabe, John W.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272448/
https://www.ncbi.nlm.nih.gov/pubmed/22230954
http://dx.doi.org/10.1038/nature10728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272448/
https://www.ncbi.nlm.nih.gov/pubmed/22230954
http://dx.doi.org/10.1038/nature10728

Ejemplares similares