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Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage

It has been twenty years since the first paper reporting the association between thyroid antibodies (TAIs) and spontaneous miscarriage was published. Following this observation, several studies have clearly demonstrated an increased prevalence of TAI in patients with recurrent miscarriage (RM). Howe...

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Autores principales: Lazzarin, Natalia, Moretti, Costanzo, De Felice, Giovanna, Vaquero, Elena, Manfellotto, Dario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272809/
https://www.ncbi.nlm.nih.gov/pubmed/22319528
http://dx.doi.org/10.1155/2012/717185
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author Lazzarin, Natalia
Moretti, Costanzo
De Felice, Giovanna
Vaquero, Elena
Manfellotto, Dario
author_facet Lazzarin, Natalia
Moretti, Costanzo
De Felice, Giovanna
Vaquero, Elena
Manfellotto, Dario
author_sort Lazzarin, Natalia
collection PubMed
description It has been twenty years since the first paper reporting the association between thyroid antibodies (TAIs) and spontaneous miscarriage was published. Following this observation, several studies have clearly demonstrated an increased prevalence of TAI in patients with recurrent miscarriage (RM). However, the exact mechanism underlying this association remains a matter of debate. The aim of the present study was to evaluate the thyroid function, throughout a specific test, in patient with RM and TAI focusing on the hypothesis that TAI should be an indirect sign of a mild thyroid dysfunction. 46 patients with RM and TAI were included in the study. All patients underwent short TRH stimulation test showing an abnormal response in the vast majority of cases (65%). Normal FT4 and FT3 mean values were found whereas TSH values were in the upper normal range (2.64 ± 1.3 mUI/L). Our data support the hypothesis that in patients with RM the presence of TAI is an indirect sign of a subtle thyroid dysfunction detectable by a specific test. This test give the possibility to identify women with RM in which specific therapeutic approaches could effectively improve the possibility for a successful pregnancy.
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spelling pubmed-32728092012-02-08 Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage Lazzarin, Natalia Moretti, Costanzo De Felice, Giovanna Vaquero, Elena Manfellotto, Dario Int J Endocrinol Clinical Study It has been twenty years since the first paper reporting the association between thyroid antibodies (TAIs) and spontaneous miscarriage was published. Following this observation, several studies have clearly demonstrated an increased prevalence of TAI in patients with recurrent miscarriage (RM). However, the exact mechanism underlying this association remains a matter of debate. The aim of the present study was to evaluate the thyroid function, throughout a specific test, in patient with RM and TAI focusing on the hypothesis that TAI should be an indirect sign of a mild thyroid dysfunction. 46 patients with RM and TAI were included in the study. All patients underwent short TRH stimulation test showing an abnormal response in the vast majority of cases (65%). Normal FT4 and FT3 mean values were found whereas TSH values were in the upper normal range (2.64 ± 1.3 mUI/L). Our data support the hypothesis that in patients with RM the presence of TAI is an indirect sign of a subtle thyroid dysfunction detectable by a specific test. This test give the possibility to identify women with RM in which specific therapeutic approaches could effectively improve the possibility for a successful pregnancy. Hindawi Publishing Corporation 2012 2012-01-26 /pmc/articles/PMC3272809/ /pubmed/22319528 http://dx.doi.org/10.1155/2012/717185 Text en Copyright © 2012 Natalia Lazzarin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Lazzarin, Natalia
Moretti, Costanzo
De Felice, Giovanna
Vaquero, Elena
Manfellotto, Dario
Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage
title Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage
title_full Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage
title_fullStr Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage
title_full_unstemmed Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage
title_short Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage
title_sort further evidence on the role of thyroid autoimmunity in women with recurrent miscarriage
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272809/
https://www.ncbi.nlm.nih.gov/pubmed/22319528
http://dx.doi.org/10.1155/2012/717185
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