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Periradicular Tissue Responses to Biologically Active Molecules or MTA When Applied in Furcal Perforation of Dogs' Teeth

The aim of this study was the comparative evaluation of inflammatory reactions and tissue responses to four growth factors, or mineral trioxide aggregate (MTA), or a zinc-oxide-eugenol-based cement (IRM) as controls, when used for the repair of furcal perforations in dogs' teeth. Results showed...

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Autores principales: Zairi, Anna, Lambrianidis, Theodoros, Pantelidou, Ourania, Papadimitriou, Serafim, Tziafas, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272814/
https://www.ncbi.nlm.nih.gov/pubmed/22319529
http://dx.doi.org/10.1155/2012/257832
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author Zairi, Anna
Lambrianidis, Theodoros
Pantelidou, Ourania
Papadimitriou, Serafim
Tziafas, Dimitrios
author_facet Zairi, Anna
Lambrianidis, Theodoros
Pantelidou, Ourania
Papadimitriou, Serafim
Tziafas, Dimitrios
author_sort Zairi, Anna
collection PubMed
description The aim of this study was the comparative evaluation of inflammatory reactions and tissue responses to four growth factors, or mineral trioxide aggregate (MTA), or a zinc-oxide-eugenol-based cement (IRM) as controls, when used for the repair of furcal perforations in dogs' teeth. Results showed significantly higher inflammatory cell response in the transforming growth factorβ1 (TGFβ1) and zinc-oxide-eugenol-based cement (IRM) groups and higher rates of epithelial proliferation in the TGFβ1, basic fibroblast growth factor (bFGF), and insulin growth factor-I (IGF-I) groups compared to the MTA. Significantly higher rates of bone formation were found in the control groups compared to the osteogenic protein-1 (OP-1). Significantly higher rates of cementum formation were observed in the IGF-I and bFGF groups compared to the IRM. None of the biologically active molecules can be suggested for repairing furcal perforations, despite the fact that growth factors exerted a clear stimulatory effect on cementum formation and inhibited collagen capsule formation. MTA exhibited better results than the growth factors.
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spelling pubmed-32728142012-02-08 Periradicular Tissue Responses to Biologically Active Molecules or MTA When Applied in Furcal Perforation of Dogs' Teeth Zairi, Anna Lambrianidis, Theodoros Pantelidou, Ourania Papadimitriou, Serafim Tziafas, Dimitrios Int J Dent Research Article The aim of this study was the comparative evaluation of inflammatory reactions and tissue responses to four growth factors, or mineral trioxide aggregate (MTA), or a zinc-oxide-eugenol-based cement (IRM) as controls, when used for the repair of furcal perforations in dogs' teeth. Results showed significantly higher inflammatory cell response in the transforming growth factorβ1 (TGFβ1) and zinc-oxide-eugenol-based cement (IRM) groups and higher rates of epithelial proliferation in the TGFβ1, basic fibroblast growth factor (bFGF), and insulin growth factor-I (IGF-I) groups compared to the MTA. Significantly higher rates of bone formation were found in the control groups compared to the osteogenic protein-1 (OP-1). Significantly higher rates of cementum formation were observed in the IGF-I and bFGF groups compared to the IRM. None of the biologically active molecules can be suggested for repairing furcal perforations, despite the fact that growth factors exerted a clear stimulatory effect on cementum formation and inhibited collagen capsule formation. MTA exhibited better results than the growth factors. Hindawi Publishing Corporation 2012 2012-01-26 /pmc/articles/PMC3272814/ /pubmed/22319529 http://dx.doi.org/10.1155/2012/257832 Text en Copyright © 2012 Anna Zairi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zairi, Anna
Lambrianidis, Theodoros
Pantelidou, Ourania
Papadimitriou, Serafim
Tziafas, Dimitrios
Periradicular Tissue Responses to Biologically Active Molecules or MTA When Applied in Furcal Perforation of Dogs' Teeth
title Periradicular Tissue Responses to Biologically Active Molecules or MTA When Applied in Furcal Perforation of Dogs' Teeth
title_full Periradicular Tissue Responses to Biologically Active Molecules or MTA When Applied in Furcal Perforation of Dogs' Teeth
title_fullStr Periradicular Tissue Responses to Biologically Active Molecules or MTA When Applied in Furcal Perforation of Dogs' Teeth
title_full_unstemmed Periradicular Tissue Responses to Biologically Active Molecules or MTA When Applied in Furcal Perforation of Dogs' Teeth
title_short Periradicular Tissue Responses to Biologically Active Molecules or MTA When Applied in Furcal Perforation of Dogs' Teeth
title_sort periradicular tissue responses to biologically active molecules or mta when applied in furcal perforation of dogs' teeth
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272814/
https://www.ncbi.nlm.nih.gov/pubmed/22319529
http://dx.doi.org/10.1155/2012/257832
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