Cargando…

Canadian Valuation of EQ-5D Health States: Preliminary Value Set and Considerations for Future Valuation Studies

BACKGROUND: The EQ-5D is a preference based instrument which provides a description of a respondent's health status, and an empirically derived value for that health state often from a representative sample of the general population. It is commonly used to derive Quality Adjusted Life Year calc...

Descripción completa

Detalles Bibliográficos
Autores principales: Bansback, Nick, Tsuchiya, Aki, Brazier, John, Anis, Aslam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273479/
https://www.ncbi.nlm.nih.gov/pubmed/22328929
http://dx.doi.org/10.1371/journal.pone.0031115
_version_ 1782222945693728768
author Bansback, Nick
Tsuchiya, Aki
Brazier, John
Anis, Aslam
author_facet Bansback, Nick
Tsuchiya, Aki
Brazier, John
Anis, Aslam
author_sort Bansback, Nick
collection PubMed
description BACKGROUND: The EQ-5D is a preference based instrument which provides a description of a respondent's health status, and an empirically derived value for that health state often from a representative sample of the general population. It is commonly used to derive Quality Adjusted Life Year calculations (QALY) in economic evaluations. However, values for health states have been found to differ between countries. The objective of this study was to develop a set of values for the EQ-5D health states for use in Canada. METHODS: Values for 48 different EQ-5D health states were elicited using the Time Trade Off (TTO) via a web survey in English. A random effect model was fitted to the data to estimate values for all 243 health states of the EQ-5D. Various model specifications were explored. Comparisons with EQ-5D values from the UK and US were made. Sensitivity analysis explored different transformations of values worse than dead, and exclusion criteria of subjects. RESULTS: The final model was estimated from the values of 1145 subjects with socio-demographics broadly representative of Canadian general population with the exception of Quebec. This yielded a good fit with observed TTO values, with an overall R2 of 0.403 and a mean absolute error of 0.044. CONCLUSION: A preference-weight algorithm for Canadian studies that include the EQ-5D is developed. The primary limitations regarded the representativeness of the final sample, given the language used (English only), the method of recruitment, and the difficulty in the task. Insights into potential issues for conducting valuation studies in countries as large and diverse as Canada are gained.
format Online
Article
Text
id pubmed-3273479
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-32734792012-02-10 Canadian Valuation of EQ-5D Health States: Preliminary Value Set and Considerations for Future Valuation Studies Bansback, Nick Tsuchiya, Aki Brazier, John Anis, Aslam PLoS One Research Article BACKGROUND: The EQ-5D is a preference based instrument which provides a description of a respondent's health status, and an empirically derived value for that health state often from a representative sample of the general population. It is commonly used to derive Quality Adjusted Life Year calculations (QALY) in economic evaluations. However, values for health states have been found to differ between countries. The objective of this study was to develop a set of values for the EQ-5D health states for use in Canada. METHODS: Values for 48 different EQ-5D health states were elicited using the Time Trade Off (TTO) via a web survey in English. A random effect model was fitted to the data to estimate values for all 243 health states of the EQ-5D. Various model specifications were explored. Comparisons with EQ-5D values from the UK and US were made. Sensitivity analysis explored different transformations of values worse than dead, and exclusion criteria of subjects. RESULTS: The final model was estimated from the values of 1145 subjects with socio-demographics broadly representative of Canadian general population with the exception of Quebec. This yielded a good fit with observed TTO values, with an overall R2 of 0.403 and a mean absolute error of 0.044. CONCLUSION: A preference-weight algorithm for Canadian studies that include the EQ-5D is developed. The primary limitations regarded the representativeness of the final sample, given the language used (English only), the method of recruitment, and the difficulty in the task. Insights into potential issues for conducting valuation studies in countries as large and diverse as Canada are gained. Public Library of Science 2012-02-06 /pmc/articles/PMC3273479/ /pubmed/22328929 http://dx.doi.org/10.1371/journal.pone.0031115 Text en Bansback et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Bansback, Nick
Tsuchiya, Aki
Brazier, John
Anis, Aslam
Canadian Valuation of EQ-5D Health States: Preliminary Value Set and Considerations for Future Valuation Studies
title Canadian Valuation of EQ-5D Health States: Preliminary Value Set and Considerations for Future Valuation Studies
title_full Canadian Valuation of EQ-5D Health States: Preliminary Value Set and Considerations for Future Valuation Studies
title_fullStr Canadian Valuation of EQ-5D Health States: Preliminary Value Set and Considerations for Future Valuation Studies
title_full_unstemmed Canadian Valuation of EQ-5D Health States: Preliminary Value Set and Considerations for Future Valuation Studies
title_short Canadian Valuation of EQ-5D Health States: Preliminary Value Set and Considerations for Future Valuation Studies
title_sort canadian valuation of eq-5d health states: preliminary value set and considerations for future valuation studies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273479/
https://www.ncbi.nlm.nih.gov/pubmed/22328929
http://dx.doi.org/10.1371/journal.pone.0031115
work_keys_str_mv AT bansbacknick canadianvaluationofeq5dhealthstatespreliminaryvaluesetandconsiderationsforfuturevaluationstudies
AT tsuchiyaaki canadianvaluationofeq5dhealthstatespreliminaryvaluesetandconsiderationsforfuturevaluationstudies
AT brazierjohn canadianvaluationofeq5dhealthstatespreliminaryvaluesetandconsiderationsforfuturevaluationstudies
AT anisaslam canadianvaluationofeq5dhealthstatespreliminaryvaluesetandconsiderationsforfuturevaluationstudies