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Loss of Activity-Induced Phosphorylation of MeCP2 Enhances Synaptogenesis, LTP, and Spatial Memory
DNA methylation-dependent epigenetic mechanisms underlie the development and function of the mammalian brain. MeCP2 expresses highly in neurons, and functions as a molecular linker between DNA methylation, chromatin remodeling and transcription regulation. Previous in vitro studies showed neuronal a...
Autores principales: | Li, Hongda, Zhong, Xiaofen, Chau, Kevin Fongching, Williams, Emily Cunningham, Chang, Qiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273496/ https://www.ncbi.nlm.nih.gov/pubmed/21765426 http://dx.doi.org/10.1038/nn.2866 |
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