N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD

Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that detects and degrades mRNAs containing premature termination codons (PTCs). SMG-1-mediated Upf1 phosphorylation takes place in the decay inducing complex (DECID), which contains a ribosome, release factors, Upf1, SMG-1, an exon junct...

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Detalles Bibliográficos
Autores principales: Okada-Katsuhata, Yukiko, Yamashita, Akio, Kutsuzawa, Kei, Izumi, Natsuko, Hirahara, Fumiki, Ohno, Shigeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273798/
https://www.ncbi.nlm.nih.gov/pubmed/21965535
http://dx.doi.org/10.1093/nar/gkr791

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