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Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations

Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and rapidly degrades mRNAs containing premature termination codons (PTC). The strength of the NMD response appears to reflect multiple determinants on a target mRNA. We have previously reported that mRNAs containing PTCs in...

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Detalles Bibliográficos
Autores principales:	Peixeiro, Isabel, Inácio, Ângela, Barbosa, Cristina, Silva, Ana Luísa, Liebhaber, Stephen A., Romão, Luísa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273812/ https://www.ncbi.nlm.nih.gov/pubmed/21989405 http://dx.doi.org/10.1093/nar/gkr820

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