Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein

Human La protein is an essential factor in the biology of both coding and non-coding RNAs. In the nucleus, La binds primarily to 3′ oligoU containing RNAs, while in the cytoplasm La interacts with an array of different mRNAs lacking a 3′ UUU(OH) trailer. An example of the latter is the binding of La...

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Detalles Bibliográficos
Autores principales: Martino, Luigi, Pennell, Simon, Kelly, Geoff, Bui, Tam T. T., Kotik-Kogan, Olga, Smerdon, Stephen J., Drake, Alex F., Curry, Stephen, Conte, Maria R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273827/
https://www.ncbi.nlm.nih.gov/pubmed/22009680
http://dx.doi.org/10.1093/nar/gkr890

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