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Morphogenesis of Infectious Hepatitis C Virus Particles
More than 170 million individuals are currently infected with hepatitis C virus (HCV) worldwide and are at continuous risk of developing chronic liver disease. Since a cell culture system enabling relatively efficient propagation of HCV has become available, an increasing number of viral and host fa...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273859/ https://www.ncbi.nlm.nih.gov/pubmed/22347224 http://dx.doi.org/10.3389/fmicb.2012.00038 |
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author | Suzuki, Tetsuro |
author_facet | Suzuki, Tetsuro |
author_sort | Suzuki, Tetsuro |
collection | PubMed |
description | More than 170 million individuals are currently infected with hepatitis C virus (HCV) worldwide and are at continuous risk of developing chronic liver disease. Since a cell culture system enabling relatively efficient propagation of HCV has become available, an increasing number of viral and host factors involved in HCV particle formation have been identified. Association of the viral Core, which forms the capsid with lipid droplets appears to be prerequisite for early HCV morphogenesis. Maturation and release of HCV particles is tightly linked to very-low-density lipoprotein biogenesis. Although expression of Core as well as E1 and E2 envelope proteins produces virus-like particles in heterologous expression systems, there is increasing evidence that non-structural viral proteins and p7 are also required for the production of infectious particles, suggesting that HCV genome replication and virion assembly are closely linked. Advances in our understanding of the various molecular mechanisms by which infectious HCV particles are formed are summarized. |
format | Online Article Text |
id | pubmed-3273859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32738592012-02-15 Morphogenesis of Infectious Hepatitis C Virus Particles Suzuki, Tetsuro Front Microbiol Microbiology More than 170 million individuals are currently infected with hepatitis C virus (HCV) worldwide and are at continuous risk of developing chronic liver disease. Since a cell culture system enabling relatively efficient propagation of HCV has become available, an increasing number of viral and host factors involved in HCV particle formation have been identified. Association of the viral Core, which forms the capsid with lipid droplets appears to be prerequisite for early HCV morphogenesis. Maturation and release of HCV particles is tightly linked to very-low-density lipoprotein biogenesis. Although expression of Core as well as E1 and E2 envelope proteins produces virus-like particles in heterologous expression systems, there is increasing evidence that non-structural viral proteins and p7 are also required for the production of infectious particles, suggesting that HCV genome replication and virion assembly are closely linked. Advances in our understanding of the various molecular mechanisms by which infectious HCV particles are formed are summarized. Frontiers Research Foundation 2012-02-07 /pmc/articles/PMC3273859/ /pubmed/22347224 http://dx.doi.org/10.3389/fmicb.2012.00038 Text en Copyright © 2012 Suzuki. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
spellingShingle | Microbiology Suzuki, Tetsuro Morphogenesis of Infectious Hepatitis C Virus Particles |
title | Morphogenesis of Infectious Hepatitis C Virus Particles |
title_full | Morphogenesis of Infectious Hepatitis C Virus Particles |
title_fullStr | Morphogenesis of Infectious Hepatitis C Virus Particles |
title_full_unstemmed | Morphogenesis of Infectious Hepatitis C Virus Particles |
title_short | Morphogenesis of Infectious Hepatitis C Virus Particles |
title_sort | morphogenesis of infectious hepatitis c virus particles |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273859/ https://www.ncbi.nlm.nih.gov/pubmed/22347224 http://dx.doi.org/10.3389/fmicb.2012.00038 |
work_keys_str_mv | AT suzukitetsuro morphogenesisofinfectioushepatitiscvirusparticles |