Molecular damage in cancer: an argument for mTOR-driven aging

Despite common belief, accumulation of molecular damage does not play a key role in aging. Still, cancer (an age-related disease) is initiated by molecular damage. Cancer and aging share a lot in common including the activation of the TOR pathway. But the role of molecular damage distinguishes cance...

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Detalles Bibliográficos
Autor principal: Blagosklonny, Mikhail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273893/
https://www.ncbi.nlm.nih.gov/pubmed/22246147
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author Blagosklonny, Mikhail V.
author_facet Blagosklonny, Mikhail V.
author_sort Blagosklonny, Mikhail V.
collection PubMed
description Despite common belief, accumulation of molecular damage does not play a key role in aging. Still, cancer (an age-related disease) is initiated by molecular damage. Cancer and aging share a lot in common including the activation of the TOR pathway. But the role of molecular damage distinguishes cancer and aging. Furthermore, an analysis of the role of both damage and aging in cancer argues against “a decline, caused by accumulation of molecular damage” as a cause of aging. I also discuss how random molecular damage, via rounds of multiplication and selection, brings about non-random hallmarks of cancer.
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spelling pubmed-32738932012-02-14 Molecular damage in cancer: an argument for mTOR-driven aging Blagosklonny, Mikhail V. Aging (Albany NY) Hypothesis Despite common belief, accumulation of molecular damage does not play a key role in aging. Still, cancer (an age-related disease) is initiated by molecular damage. Cancer and aging share a lot in common including the activation of the TOR pathway. But the role of molecular damage distinguishes cancer and aging. Furthermore, an analysis of the role of both damage and aging in cancer argues against “a decline, caused by accumulation of molecular damage” as a cause of aging. I also discuss how random molecular damage, via rounds of multiplication and selection, brings about non-random hallmarks of cancer. Impact Journals LLC 2011-12-31 /pmc/articles/PMC3273893/ /pubmed/22246147 Text en Copyright: © 2011 Blagosklonny http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Hypothesis
Blagosklonny, Mikhail V.
Molecular damage in cancer: an argument for mTOR-driven aging
title Molecular damage in cancer: an argument for mTOR-driven aging
title_full Molecular damage in cancer: an argument for mTOR-driven aging
title_fullStr Molecular damage in cancer: an argument for mTOR-driven aging
title_full_unstemmed Molecular damage in cancer: an argument for mTOR-driven aging
title_short Molecular damage in cancer: an argument for mTOR-driven aging
title_sort molecular damage in cancer: an argument for mtor-driven aging
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273893/
https://www.ncbi.nlm.nih.gov/pubmed/22246147
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