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Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells

BACKGROUND: Activated proximal tubular cells play an important role in renal fibrosis. We investigated whether sunitinib and a kidney-targeted conjugate of sunitinib were capable of attenuating fibrogenic events in tubulointerstitial fibrosis. METHODS: A kidney-targeted conjugate was prepared by lin...

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Detalles Bibliográficos
Autores principales:	Dolman, ME (Emmy) M, Harmsen, Stefan, Pieters, Ebel HE, Sparidans, Rolf W, Lacombe, Marie, Szokol, Bálint, Őrfi, László, Kéri, György, Storm, Gert, Hennink, Wim E, Kok, Robbert J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2012
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273977/ https://www.ncbi.nlm.nih.gov/pubmed/22334775 http://dx.doi.org/10.2147/IJN.S26485

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