Homology-directed Fanconi anemia pathway crosslink repair is dependent on DNA replication

Homologous recombination (also termed homology-directed repair, HDR) is a major pathway for the repair of DNA interstrand crosslinks (ICLs) in mammalian cells. Cells from Fanconi anemia (FA) patients are characterized by extreme ICL sensitivity, but their reported defect in HDR is mild. Here, we exa...

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Autores principales: Nakanishi, Koji, Cavallo, Francesca, Perrouault, Loïc, Giovannangeli, Carine, Moynahan, Mary Ellen, Barchi, Marco, Brunet, Erika, Jasin, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273992/
https://www.ncbi.nlm.nih.gov/pubmed/21423196
http://dx.doi.org/10.1038/nsmb.2029
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author Nakanishi, Koji
Cavallo, Francesca
Perrouault, Loïc
Giovannangeli, Carine
Moynahan, Mary Ellen
Barchi, Marco
Brunet, Erika
Jasin, Maria
author_facet Nakanishi, Koji
Cavallo, Francesca
Perrouault, Loïc
Giovannangeli, Carine
Moynahan, Mary Ellen
Barchi, Marco
Brunet, Erika
Jasin, Maria
author_sort Nakanishi, Koji
collection PubMed
description Homologous recombination (also termed homology-directed repair, HDR) is a major pathway for the repair of DNA interstrand crosslinks (ICLs) in mammalian cells. Cells from Fanconi anemia (FA) patients are characterized by extreme ICL sensitivity, but their reported defect in HDR is mild. Here, we examined ICL-induced HDR using a GFP reporter and observed a profound defect in ICL-induced HDR in FA cells, but only when the reporter could replicate.
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spelling pubmed-32739922012-02-07 Homology-directed Fanconi anemia pathway crosslink repair is dependent on DNA replication Nakanishi, Koji Cavallo, Francesca Perrouault, Loïc Giovannangeli, Carine Moynahan, Mary Ellen Barchi, Marco Brunet, Erika Jasin, Maria Nat Struct Mol Biol Article Homologous recombination (also termed homology-directed repair, HDR) is a major pathway for the repair of DNA interstrand crosslinks (ICLs) in mammalian cells. Cells from Fanconi anemia (FA) patients are characterized by extreme ICL sensitivity, but their reported defect in HDR is mild. Here, we examined ICL-induced HDR using a GFP reporter and observed a profound defect in ICL-induced HDR in FA cells, but only when the reporter could replicate. 2011-03-20 2011-04 /pmc/articles/PMC3273992/ /pubmed/21423196 http://dx.doi.org/10.1038/nsmb.2029 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Nakanishi, Koji
Cavallo, Francesca
Perrouault, Loïc
Giovannangeli, Carine
Moynahan, Mary Ellen
Barchi, Marco
Brunet, Erika
Jasin, Maria
Homology-directed Fanconi anemia pathway crosslink repair is dependent on DNA replication
title Homology-directed Fanconi anemia pathway crosslink repair is dependent on DNA replication
title_full Homology-directed Fanconi anemia pathway crosslink repair is dependent on DNA replication
title_fullStr Homology-directed Fanconi anemia pathway crosslink repair is dependent on DNA replication
title_full_unstemmed Homology-directed Fanconi anemia pathway crosslink repair is dependent on DNA replication
title_short Homology-directed Fanconi anemia pathway crosslink repair is dependent on DNA replication
title_sort homology-directed fanconi anemia pathway crosslink repair is dependent on dna replication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273992/
https://www.ncbi.nlm.nih.gov/pubmed/21423196
http://dx.doi.org/10.1038/nsmb.2029
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