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Alternative Post-Processing on a CMOS Chip to Fabricate a Planar Microelectrode Array

We present an alternative post-processing on a CMOS chip to release a planar microelectrode array (pMEA) integrated with its signal readout circuit, which can be used for monitoring the neuronal activity of vestibular ganglion neurons in newborn Wistar strain rats. This chip is fabricated through a...

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Autores principales: López-Huerta, Francisco, Herrera-May, Agustín L., Estrada-López, Johan J., Zuñiga-Islas, Carlos, Cervantes-Sanchez, Blanca, Soto, Enrique, Soto-Cruz, Blanca S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274323/
https://www.ncbi.nlm.nih.gov/pubmed/22346681
http://dx.doi.org/10.3390/s111110940
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author López-Huerta, Francisco
Herrera-May, Agustín L.
Estrada-López, Johan J.
Zuñiga-Islas, Carlos
Cervantes-Sanchez, Blanca
Soto, Enrique
Soto-Cruz, Blanca S.
author_facet López-Huerta, Francisco
Herrera-May, Agustín L.
Estrada-López, Johan J.
Zuñiga-Islas, Carlos
Cervantes-Sanchez, Blanca
Soto, Enrique
Soto-Cruz, Blanca S.
author_sort López-Huerta, Francisco
collection PubMed
description We present an alternative post-processing on a CMOS chip to release a planar microelectrode array (pMEA) integrated with its signal readout circuit, which can be used for monitoring the neuronal activity of vestibular ganglion neurons in newborn Wistar strain rats. This chip is fabricated through a 0.6 μm CMOS standard process and it has 12 pMEA through a 4 × 3 electrodes matrix. The alternative CMOS post-process includes the development of masks to protect the readout circuit and the power supply pads. A wet etching process eliminates the aluminum located on the surface of the p(+)-type silicon. This silicon is used as transducer for recording the neuronal activity and as interface between the readout circuit and neurons. The readout circuit is composed of an amplifier and tunable bandpass filter, which is placed on a 0.015 mm(2) silicon area. The tunable bandpass filter has a bandwidth of 98 kHz and a common mode rejection ratio (CMRR) of 87 dB. These characteristics of the readout circuit are appropriate for neuronal recording applications.
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spelling pubmed-32743232012-02-15 Alternative Post-Processing on a CMOS Chip to Fabricate a Planar Microelectrode Array López-Huerta, Francisco Herrera-May, Agustín L. Estrada-López, Johan J. Zuñiga-Islas, Carlos Cervantes-Sanchez, Blanca Soto, Enrique Soto-Cruz, Blanca S. Sensors (Basel) Article We present an alternative post-processing on a CMOS chip to release a planar microelectrode array (pMEA) integrated with its signal readout circuit, which can be used for monitoring the neuronal activity of vestibular ganglion neurons in newborn Wistar strain rats. This chip is fabricated through a 0.6 μm CMOS standard process and it has 12 pMEA through a 4 × 3 electrodes matrix. The alternative CMOS post-process includes the development of masks to protect the readout circuit and the power supply pads. A wet etching process eliminates the aluminum located on the surface of the p(+)-type silicon. This silicon is used as transducer for recording the neuronal activity and as interface between the readout circuit and neurons. The readout circuit is composed of an amplifier and tunable bandpass filter, which is placed on a 0.015 mm(2) silicon area. The tunable bandpass filter has a bandwidth of 98 kHz and a common mode rejection ratio (CMRR) of 87 dB. These characteristics of the readout circuit are appropriate for neuronal recording applications. Molecular Diversity Preservation International (MDPI) 2011-11-22 /pmc/articles/PMC3274323/ /pubmed/22346681 http://dx.doi.org/10.3390/s111110940 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
López-Huerta, Francisco
Herrera-May, Agustín L.
Estrada-López, Johan J.
Zuñiga-Islas, Carlos
Cervantes-Sanchez, Blanca
Soto, Enrique
Soto-Cruz, Blanca S.
Alternative Post-Processing on a CMOS Chip to Fabricate a Planar Microelectrode Array
title Alternative Post-Processing on a CMOS Chip to Fabricate a Planar Microelectrode Array
title_full Alternative Post-Processing on a CMOS Chip to Fabricate a Planar Microelectrode Array
title_fullStr Alternative Post-Processing on a CMOS Chip to Fabricate a Planar Microelectrode Array
title_full_unstemmed Alternative Post-Processing on a CMOS Chip to Fabricate a Planar Microelectrode Array
title_short Alternative Post-Processing on a CMOS Chip to Fabricate a Planar Microelectrode Array
title_sort alternative post-processing on a cmos chip to fabricate a planar microelectrode array
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274323/
https://www.ncbi.nlm.nih.gov/pubmed/22346681
http://dx.doi.org/10.3390/s111110940
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