Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection

Hepatocyte nuclear factors 4 alpha (HNF4α) and 3 beta (HNF3β) are members of a group of liver-enriched transcription factors (LETFs) that play important roles in regulating the replication of hepatitis B virus (HBV) and liver inflammation. However, the relationship of the level of HNF4α and HNF3β wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, En-Qiang, Sun, Hui, Feng, Ping, Gong, Dao-Yin, Liu, Cong, Bai, Lang, Yang, Wen-Bing, Lei, Xue-Zhong, Chen, Li-Yu, Huang, Fei-Jun, Tang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274429/
https://www.ncbi.nlm.nih.gov/pubmed/22257755
http://dx.doi.org/10.1186/1743-422X-9-23
_version_ 1782223064869634048
author Chen, En-Qiang
Sun, Hui
Feng, Ping
Gong, Dao-Yin
Liu, Cong
Bai, Lang
Yang, Wen-Bing
Lei, Xue-Zhong
Chen, Li-Yu
Huang, Fei-Jun
Tang, Hong
author_facet Chen, En-Qiang
Sun, Hui
Feng, Ping
Gong, Dao-Yin
Liu, Cong
Bai, Lang
Yang, Wen-Bing
Lei, Xue-Zhong
Chen, Li-Yu
Huang, Fei-Jun
Tang, Hong
author_sort Chen, En-Qiang
collection PubMed
description Hepatocyte nuclear factors 4 alpha (HNF4α) and 3 beta (HNF3β) are members of a group of liver-enriched transcription factors (LETFs) that play important roles in regulating the replication of hepatitis B virus (HBV) and liver inflammation. However, the relationship of the level of HNF4α and HNF3β with the severity of HBV-infected liver diseases is unclear. In this study, liver tissue samples from different types of HBV patients were collected, and HNF4α and HNF3β expression were detected by immunohistochemistry. The expression of HNF4α was significant higher in patients with severe hepatitis B(SHB) than those with chronic hepatitis B(CHB) and liver cirrhosis(LC) (both P < 0.05), but similar between patients with CHB and LC (P > 0.05). And the expression of HNF3β was similar among patients with CHB, LC and SHB (P > 0.05 for all pairwise comparison). This suggests that the expression level of HNF4α was different in patients with different outcome of HBV infection, high expression level of HNF4α may correlate with occurrence of SHB
format Online
Article
Text
id pubmed-3274429
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-32744292012-02-08 Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection Chen, En-Qiang Sun, Hui Feng, Ping Gong, Dao-Yin Liu, Cong Bai, Lang Yang, Wen-Bing Lei, Xue-Zhong Chen, Li-Yu Huang, Fei-Jun Tang, Hong Virol J Research Hepatocyte nuclear factors 4 alpha (HNF4α) and 3 beta (HNF3β) are members of a group of liver-enriched transcription factors (LETFs) that play important roles in regulating the replication of hepatitis B virus (HBV) and liver inflammation. However, the relationship of the level of HNF4α and HNF3β with the severity of HBV-infected liver diseases is unclear. In this study, liver tissue samples from different types of HBV patients were collected, and HNF4α and HNF3β expression were detected by immunohistochemistry. The expression of HNF4α was significant higher in patients with severe hepatitis B(SHB) than those with chronic hepatitis B(CHB) and liver cirrhosis(LC) (both P < 0.05), but similar between patients with CHB and LC (P > 0.05). And the expression of HNF3β was similar among patients with CHB, LC and SHB (P > 0.05 for all pairwise comparison). This suggests that the expression level of HNF4α was different in patients with different outcome of HBV infection, high expression level of HNF4α may correlate with occurrence of SHB BioMed Central 2012-01-18 /pmc/articles/PMC3274429/ /pubmed/22257755 http://dx.doi.org/10.1186/1743-422X-9-23 Text en Copyright ©2012 Chen et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Chen, En-Qiang
Sun, Hui
Feng, Ping
Gong, Dao-Yin
Liu, Cong
Bai, Lang
Yang, Wen-Bing
Lei, Xue-Zhong
Chen, Li-Yu
Huang, Fei-Jun
Tang, Hong
Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection
title Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection
title_full Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection
title_fullStr Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection
title_full_unstemmed Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection
title_short Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection
title_sort study of the expression levels of hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of hbv infection
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274429/
https://www.ncbi.nlm.nih.gov/pubmed/22257755
http://dx.doi.org/10.1186/1743-422X-9-23
work_keys_str_mv AT chenenqiang studyoftheexpressionlevelsofhepatocytenuclearfactor4alphaand3betainpatientswithdifferentoutcomeofhbvinfection
AT sunhui studyoftheexpressionlevelsofhepatocytenuclearfactor4alphaand3betainpatientswithdifferentoutcomeofhbvinfection
AT fengping studyoftheexpressionlevelsofhepatocytenuclearfactor4alphaand3betainpatientswithdifferentoutcomeofhbvinfection
AT gongdaoyin studyoftheexpressionlevelsofhepatocytenuclearfactor4alphaand3betainpatientswithdifferentoutcomeofhbvinfection
AT liucong studyoftheexpressionlevelsofhepatocytenuclearfactor4alphaand3betainpatientswithdifferentoutcomeofhbvinfection
AT bailang studyoftheexpressionlevelsofhepatocytenuclearfactor4alphaand3betainpatientswithdifferentoutcomeofhbvinfection
AT yangwenbing studyoftheexpressionlevelsofhepatocytenuclearfactor4alphaand3betainpatientswithdifferentoutcomeofhbvinfection
AT leixuezhong studyoftheexpressionlevelsofhepatocytenuclearfactor4alphaand3betainpatientswithdifferentoutcomeofhbvinfection
AT chenliyu studyoftheexpressionlevelsofhepatocytenuclearfactor4alphaand3betainpatientswithdifferentoutcomeofhbvinfection
AT huangfeijun studyoftheexpressionlevelsofhepatocytenuclearfactor4alphaand3betainpatientswithdifferentoutcomeofhbvinfection
AT tanghong studyoftheexpressionlevelsofhepatocytenuclearfactor4alphaand3betainpatientswithdifferentoutcomeofhbvinfection

Ejemplares similares