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Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection
Through their domestication and subsequent selection, sheep have been adapted to thrive in a diverse range of environments. To characterise the genetic consequence of both domestication and selection, we genotyped 49,034 SNP in 2,819 animals from a diverse collection of 74 sheep breeds. We find the...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274507/ https://www.ncbi.nlm.nih.gov/pubmed/22346734 http://dx.doi.org/10.1371/journal.pbio.1001258 |
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author | Kijas, James W. Lenstra, Johannes A. Hayes, Ben Boitard, Simon Porto Neto, Laercio R. San Cristobal, Magali Servin, Bertrand McCulloch, Russell Whan, Vicki Gietzen, Kimberly Paiva, Samuel Barendse, William Ciani, Elena Raadsma, Herman McEwan, John Dalrymple, Brian |
author_facet | Kijas, James W. Lenstra, Johannes A. Hayes, Ben Boitard, Simon Porto Neto, Laercio R. San Cristobal, Magali Servin, Bertrand McCulloch, Russell Whan, Vicki Gietzen, Kimberly Paiva, Samuel Barendse, William Ciani, Elena Raadsma, Herman McEwan, John Dalrymple, Brian |
author_sort | Kijas, James W. |
collection | PubMed |
description | Through their domestication and subsequent selection, sheep have been adapted to thrive in a diverse range of environments. To characterise the genetic consequence of both domestication and selection, we genotyped 49,034 SNP in 2,819 animals from a diverse collection of 74 sheep breeds. We find the majority of sheep populations contain high SNP diversity and have retained an effective population size much higher than most cattle or dog breeds, suggesting domestication occurred from a broad genetic base. Extensive haplotype sharing and generally low divergence time between breeds reveal frequent genetic exchange has occurred during the development of modern breeds. A scan of the genome for selection signals revealed 31 regions containing genes for coat pigmentation, skeletal morphology, body size, growth, and reproduction. We demonstrate the strongest selection signal has occurred in response to breeding for the absence of horns. The high density map of genetic variability provides an in-depth view of the genetic history for this important livestock species. |
format | Online Article Text |
id | pubmed-3274507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-32745072012-02-15 Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection Kijas, James W. Lenstra, Johannes A. Hayes, Ben Boitard, Simon Porto Neto, Laercio R. San Cristobal, Magali Servin, Bertrand McCulloch, Russell Whan, Vicki Gietzen, Kimberly Paiva, Samuel Barendse, William Ciani, Elena Raadsma, Herman McEwan, John Dalrymple, Brian PLoS Biol Research Article Through their domestication and subsequent selection, sheep have been adapted to thrive in a diverse range of environments. To characterise the genetic consequence of both domestication and selection, we genotyped 49,034 SNP in 2,819 animals from a diverse collection of 74 sheep breeds. We find the majority of sheep populations contain high SNP diversity and have retained an effective population size much higher than most cattle or dog breeds, suggesting domestication occurred from a broad genetic base. Extensive haplotype sharing and generally low divergence time between breeds reveal frequent genetic exchange has occurred during the development of modern breeds. A scan of the genome for selection signals revealed 31 regions containing genes for coat pigmentation, skeletal morphology, body size, growth, and reproduction. We demonstrate the strongest selection signal has occurred in response to breeding for the absence of horns. The high density map of genetic variability provides an in-depth view of the genetic history for this important livestock species. Public Library of Science 2012-02-07 /pmc/articles/PMC3274507/ /pubmed/22346734 http://dx.doi.org/10.1371/journal.pbio.1001258 Text en Kijas et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Kijas, James W. Lenstra, Johannes A. Hayes, Ben Boitard, Simon Porto Neto, Laercio R. San Cristobal, Magali Servin, Bertrand McCulloch, Russell Whan, Vicki Gietzen, Kimberly Paiva, Samuel Barendse, William Ciani, Elena Raadsma, Herman McEwan, John Dalrymple, Brian Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection |
title | Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection |
title_full | Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection |
title_fullStr | Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection |
title_full_unstemmed | Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection |
title_short | Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection |
title_sort | genome-wide analysis of the world's sheep breeds reveals high levels of historic mixture and strong recent selection |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274507/ https://www.ncbi.nlm.nih.gov/pubmed/22346734 http://dx.doi.org/10.1371/journal.pbio.1001258 |
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