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Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection

Through their domestication and subsequent selection, sheep have been adapted to thrive in a diverse range of environments. To characterise the genetic consequence of both domestication and selection, we genotyped 49,034 SNP in 2,819 animals from a diverse collection of 74 sheep breeds. We find the...

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Autores principales: Kijas, James W., Lenstra, Johannes A., Hayes, Ben, Boitard, Simon, Porto Neto, Laercio R., San Cristobal, Magali, Servin, Bertrand, McCulloch, Russell, Whan, Vicki, Gietzen, Kimberly, Paiva, Samuel, Barendse, William, Ciani, Elena, Raadsma, Herman, McEwan, John, Dalrymple, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274507/
https://www.ncbi.nlm.nih.gov/pubmed/22346734
http://dx.doi.org/10.1371/journal.pbio.1001258
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author Kijas, James W.
Lenstra, Johannes A.
Hayes, Ben
Boitard, Simon
Porto Neto, Laercio R.
San Cristobal, Magali
Servin, Bertrand
McCulloch, Russell
Whan, Vicki
Gietzen, Kimberly
Paiva, Samuel
Barendse, William
Ciani, Elena
Raadsma, Herman
McEwan, John
Dalrymple, Brian
author_facet Kijas, James W.
Lenstra, Johannes A.
Hayes, Ben
Boitard, Simon
Porto Neto, Laercio R.
San Cristobal, Magali
Servin, Bertrand
McCulloch, Russell
Whan, Vicki
Gietzen, Kimberly
Paiva, Samuel
Barendse, William
Ciani, Elena
Raadsma, Herman
McEwan, John
Dalrymple, Brian
author_sort Kijas, James W.
collection PubMed
description Through their domestication and subsequent selection, sheep have been adapted to thrive in a diverse range of environments. To characterise the genetic consequence of both domestication and selection, we genotyped 49,034 SNP in 2,819 animals from a diverse collection of 74 sheep breeds. We find the majority of sheep populations contain high SNP diversity and have retained an effective population size much higher than most cattle or dog breeds, suggesting domestication occurred from a broad genetic base. Extensive haplotype sharing and generally low divergence time between breeds reveal frequent genetic exchange has occurred during the development of modern breeds. A scan of the genome for selection signals revealed 31 regions containing genes for coat pigmentation, skeletal morphology, body size, growth, and reproduction. We demonstrate the strongest selection signal has occurred in response to breeding for the absence of horns. The high density map of genetic variability provides an in-depth view of the genetic history for this important livestock species.
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spelling pubmed-32745072012-02-15 Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection Kijas, James W. Lenstra, Johannes A. Hayes, Ben Boitard, Simon Porto Neto, Laercio R. San Cristobal, Magali Servin, Bertrand McCulloch, Russell Whan, Vicki Gietzen, Kimberly Paiva, Samuel Barendse, William Ciani, Elena Raadsma, Herman McEwan, John Dalrymple, Brian PLoS Biol Research Article Through their domestication and subsequent selection, sheep have been adapted to thrive in a diverse range of environments. To characterise the genetic consequence of both domestication and selection, we genotyped 49,034 SNP in 2,819 animals from a diverse collection of 74 sheep breeds. We find the majority of sheep populations contain high SNP diversity and have retained an effective population size much higher than most cattle or dog breeds, suggesting domestication occurred from a broad genetic base. Extensive haplotype sharing and generally low divergence time between breeds reveal frequent genetic exchange has occurred during the development of modern breeds. A scan of the genome for selection signals revealed 31 regions containing genes for coat pigmentation, skeletal morphology, body size, growth, and reproduction. We demonstrate the strongest selection signal has occurred in response to breeding for the absence of horns. The high density map of genetic variability provides an in-depth view of the genetic history for this important livestock species. Public Library of Science 2012-02-07 /pmc/articles/PMC3274507/ /pubmed/22346734 http://dx.doi.org/10.1371/journal.pbio.1001258 Text en Kijas et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kijas, James W.
Lenstra, Johannes A.
Hayes, Ben
Boitard, Simon
Porto Neto, Laercio R.
San Cristobal, Magali
Servin, Bertrand
McCulloch, Russell
Whan, Vicki
Gietzen, Kimberly
Paiva, Samuel
Barendse, William
Ciani, Elena
Raadsma, Herman
McEwan, John
Dalrymple, Brian
Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection
title Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection
title_full Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection
title_fullStr Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection
title_full_unstemmed Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection
title_short Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection
title_sort genome-wide analysis of the world's sheep breeds reveals high levels of historic mixture and strong recent selection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274507/
https://www.ncbi.nlm.nih.gov/pubmed/22346734
http://dx.doi.org/10.1371/journal.pbio.1001258
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