Ubiquitin-Specific Protease 4 Inhibits Mono-Ubiquitination of the Master Growth Factor Signaling Kinase PDK1

BACKGROUND: Phosphorylation by the phospho-inositide-dependent kinase 1 (PDK1) is essential for many growth factor-activated kinases and thus plays a critical role in various processes such as cell proliferation and metabolism. However, the mechanisms that control PDK1 have not been fully explored a...

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Detalles Bibliográficos
Autores principales: Uras, Iris Z., List, Thomas, Nijman, Sebastian M. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274522/
https://www.ncbi.nlm.nih.gov/pubmed/22347420
http://dx.doi.org/10.1371/journal.pone.0031003

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