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The Thermal Structural Transition of Alpha-Crystallin Modulates Subunit Interactions and Increases Protein Solubility

BACKGROUND: Alpha crystallin is an oligomer composed of two types of subunits, alpha-A and alpha-B crystallin, and is the major constituent of human lens. The temperature induced condensation of alpha-crystallin, the main cause for eye lens opacification (cataract), is a two step-process, a nucleati...

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Detalles Bibliográficos
Autores principales:	Maulucci, Giuseppe, De Spirito, Marco, Arcovito, Giuseppe, Papi, Massimiliano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274527/ https://www.ncbi.nlm.nih.gov/pubmed/22347398 http://dx.doi.org/10.1371/journal.pone.0030705

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