Radiosensitization of Normoxic and Hypoxic H1339 Lung Tumor Cells by Heat Shock Protein 90 Inhibition Is Independent of Hypoxia Inducible Factor-1α

BACKGROUND: Ionizing irradiation is a commonly accepted treatment modality for lung cancer patients. However, the clinical outcome is hampered by normal tissue toxicity and tumor hypoxia. Since tumors often have higher levels of active heat shock protein 90 (Hsp90) than normal tissues, targeting of...

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Detalles Bibliográficos
Autores principales: Schilling, Daniela, Bayer, Christine, Li, Wei, Molls, Michael, Vaupel, Peter, Multhoff, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274537/
https://www.ncbi.nlm.nih.gov/pubmed/22347438
http://dx.doi.org/10.1371/journal.pone.0031110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274537/
https://www.ncbi.nlm.nih.gov/pubmed/22347438
http://dx.doi.org/10.1371/journal.pone.0031110

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