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The Inherited Blindness Protein AIPL1 Regulates the Ubiquitin-Like FAT10 Pathway

Mutations in AIPL1 cause the inherited blindness Leber congenital amaurosis (LCA). AIPL1 has previously been shown to interact with NUB1, which facilitates the proteasomal degradation of proteins modified with the ubiquitin-like protein FAT10. Here we report that AIPL1 binds non-covalently to free F...

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Detalles Bibliográficos
Autores principales:	Bett, John S., Kanuga, Naheed, Richet, Emma, Schmidtke, Gunter, Groettrup, Marcus, Cheetham, Michael E., van der Spuy, Jacqueline
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274541/ https://www.ncbi.nlm.nih.gov/pubmed/22347407 http://dx.doi.org/10.1371/journal.pone.0030866

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