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Effect of CGRP and sumatriptan on the BOLD response in visual cortex

To test the hypothesis that calcitonin gene-related peptide (CGRP) modulates brain activity, we investigated the effect of intravenous CGRP on brain activity in response to a visual stimulus. In addition, we examined if possible alteration in brain activity was reversed by the anti-migraine drug sum...

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Autores principales: Asghar, Mohammad S., Hansen, Adam E., Larsson, Henrik B. W., Olesen, Jes, Ashina, Messoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274575/
https://www.ncbi.nlm.nih.gov/pubmed/22246026
http://dx.doi.org/10.1007/s10194-011-0415-4
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author Asghar, Mohammad S.
Hansen, Adam E.
Larsson, Henrik B. W.
Olesen, Jes
Ashina, Messoud
author_facet Asghar, Mohammad S.
Hansen, Adam E.
Larsson, Henrik B. W.
Olesen, Jes
Ashina, Messoud
author_sort Asghar, Mohammad S.
collection PubMed
description To test the hypothesis that calcitonin gene-related peptide (CGRP) modulates brain activity, we investigated the effect of intravenous CGRP on brain activity in response to a visual stimulus. In addition, we examined if possible alteration in brain activity was reversed by the anti-migraine drug sumatriptan. Eighteen healthy volunteers were randomly allocated to receive CGRP infusion (1.5 μg/min for 20 min) or placebo. In vivo activity in the visual cortex was recorded before, during and after infusion and after 6 mg subcutaneous sumatriptan by functional magnetic resonance imaging (3 T). 77% of the participants reported headache after CGRP. We found no changes in brain activity after CGRP (P = 0.12) or after placebo (P = 0.41). Sumatriptan did not affect brain activity after CGRP (P = 0.71) or after placebo (P = 0.98). Systemic CGRP or sumatriptan has no direct effects on the BOLD activity in visual cortex. This suggests that in healthy volunteers both CGRP and sumatriptan may exert their actions outside of the blood–brain barrier. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10194-011-0415-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-32745752012-02-21 Effect of CGRP and sumatriptan on the BOLD response in visual cortex Asghar, Mohammad S. Hansen, Adam E. Larsson, Henrik B. W. Olesen, Jes Ashina, Messoud J Headache Pain Original To test the hypothesis that calcitonin gene-related peptide (CGRP) modulates brain activity, we investigated the effect of intravenous CGRP on brain activity in response to a visual stimulus. In addition, we examined if possible alteration in brain activity was reversed by the anti-migraine drug sumatriptan. Eighteen healthy volunteers were randomly allocated to receive CGRP infusion (1.5 μg/min for 20 min) or placebo. In vivo activity in the visual cortex was recorded before, during and after infusion and after 6 mg subcutaneous sumatriptan by functional magnetic resonance imaging (3 T). 77% of the participants reported headache after CGRP. We found no changes in brain activity after CGRP (P = 0.12) or after placebo (P = 0.41). Sumatriptan did not affect brain activity after CGRP (P = 0.71) or after placebo (P = 0.98). Systemic CGRP or sumatriptan has no direct effects on the BOLD activity in visual cortex. This suggests that in healthy volunteers both CGRP and sumatriptan may exert their actions outside of the blood–brain barrier. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10194-011-0415-4) contains supplementary material, which is available to authorized users. Springer Milan 2012-01-14 /pmc/articles/PMC3274575/ /pubmed/22246026 http://dx.doi.org/10.1007/s10194-011-0415-4 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original
Asghar, Mohammad S.
Hansen, Adam E.
Larsson, Henrik B. W.
Olesen, Jes
Ashina, Messoud
Effect of CGRP and sumatriptan on the BOLD response in visual cortex
title Effect of CGRP and sumatriptan on the BOLD response in visual cortex
title_full Effect of CGRP and sumatriptan on the BOLD response in visual cortex
title_fullStr Effect of CGRP and sumatriptan on the BOLD response in visual cortex
title_full_unstemmed Effect of CGRP and sumatriptan on the BOLD response in visual cortex
title_short Effect of CGRP and sumatriptan on the BOLD response in visual cortex
title_sort effect of cgrp and sumatriptan on the bold response in visual cortex
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274575/
https://www.ncbi.nlm.nih.gov/pubmed/22246026
http://dx.doi.org/10.1007/s10194-011-0415-4
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