Prostaglandin E(2) promotes intestinal tumor growth via DNA methylation

Although DNA methylation is one of the critical ways for silencing tumor suppressor and DNA repair genes during tumor initiation and progression, the mechanisms underlying DNA methylation in cancer remain unclear. Here we show that prostaglandin E(2) (PGE(2)) silences certain tumor suppressor and DN...

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Autores principales: Xia, Dianren, Wang, Dingzhi, Kim, Sun-Hee, Katoh, Hiroshi, DuBois, Raymond N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274627/
https://www.ncbi.nlm.nih.gov/pubmed/22270723
http://dx.doi.org/10.1038/nm.2608
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author Xia, Dianren
Wang, Dingzhi
Kim, Sun-Hee
Katoh, Hiroshi
DuBois, Raymond N.
author_facet Xia, Dianren
Wang, Dingzhi
Kim, Sun-Hee
Katoh, Hiroshi
DuBois, Raymond N.
author_sort Xia, Dianren
collection PubMed
description Although DNA methylation is one of the critical ways for silencing tumor suppressor and DNA repair genes during tumor initiation and progression, the mechanisms underlying DNA methylation in cancer remain unclear. Here we show that prostaglandin E(2) (PGE(2)) silences certain tumor suppressor and DNA repair genes via DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE(2) in the promotion of tumor progression.
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spelling pubmed-32746272012-08-01 Prostaglandin E(2) promotes intestinal tumor growth via DNA methylation Xia, Dianren Wang, Dingzhi Kim, Sun-Hee Katoh, Hiroshi DuBois, Raymond N. Nat Med Article Although DNA methylation is one of the critical ways for silencing tumor suppressor and DNA repair genes during tumor initiation and progression, the mechanisms underlying DNA methylation in cancer remain unclear. Here we show that prostaglandin E(2) (PGE(2)) silences certain tumor suppressor and DNA repair genes via DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE(2) in the promotion of tumor progression. 2012-01-22 /pmc/articles/PMC3274627/ /pubmed/22270723 http://dx.doi.org/10.1038/nm.2608 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Xia, Dianren
Wang, Dingzhi
Kim, Sun-Hee
Katoh, Hiroshi
DuBois, Raymond N.
Prostaglandin E(2) promotes intestinal tumor growth via DNA methylation
title Prostaglandin E(2) promotes intestinal tumor growth via DNA methylation
title_full Prostaglandin E(2) promotes intestinal tumor growth via DNA methylation
title_fullStr Prostaglandin E(2) promotes intestinal tumor growth via DNA methylation
title_full_unstemmed Prostaglandin E(2) promotes intestinal tumor growth via DNA methylation
title_short Prostaglandin E(2) promotes intestinal tumor growth via DNA methylation
title_sort prostaglandin e(2) promotes intestinal tumor growth via dna methylation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274627/
https://www.ncbi.nlm.nih.gov/pubmed/22270723
http://dx.doi.org/10.1038/nm.2608
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AT katohhiroshi prostaglandine2promotesintestinaltumorgrowthviadnamethylation
AT duboisraymondn prostaglandine2promotesintestinaltumorgrowthviadnamethylation

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