AICAR Prevents Heat Induced Sudden Death in RyR1 Mutant Mice Independent of AMPK Activation

Mice with a knock-in mutation (Y524S) in the type I ryanodine receptor (RyR1) die when exposed to short periods of temperature elevation (≥ 37 °C). We demonstrate that treatment with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) prevents heat-induced sudden death in Y524S mice. The AICAR pro...

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Detalles Bibliográficos
Autores principales: Lanner, Johanna T., Georgiou, Dimitra K., Dagnino-Acosta, Adan, Ainbinder, Alina, Cheng, Qing, Joshi, Aditya D., Chen, Zanwen, Yarotskyy, Viktor, Oakes, Joshua M., Lee, Chang Seok, Monroe, Tanner O., Santillan, Arturo, Dong, Keke, Goodyear, Laurie, Ismailov, Iskander I., Rodney, George G., Dirksen, Robert T., Hamilton, Susan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274651/
https://www.ncbi.nlm.nih.gov/pubmed/22231556
http://dx.doi.org/10.1038/nm.2598

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