Cargando…
Aptamers in Virology: Recent Advances and Challenges
Aptamers generated from randomized libraries of nucleic acids have found utility in a wide variety of fields and in the clinic. Aptamers can be used to target both intracellular and extracellular components, including small molecules, proteins, cells, and viruses. With recent technological developme...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Research Foundation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274758/ https://www.ncbi.nlm.nih.gov/pubmed/22347221 http://dx.doi.org/10.3389/fmicb.2012.00029 |
_version_ | 1782223113024438272 |
---|---|
author | Binning, Jennifer M. Leung, Daisy W. Amarasinghe, Gaya K. |
author_facet | Binning, Jennifer M. Leung, Daisy W. Amarasinghe, Gaya K. |
author_sort | Binning, Jennifer M. |
collection | PubMed |
description | Aptamers generated from randomized libraries of nucleic acids have found utility in a wide variety of fields and in the clinic. Aptamers can be used to target both intracellular and extracellular components, including small molecules, proteins, cells, and viruses. With recent technological developments in stringent selection and rapid isolation strategies, it is likely that aptamers will continue to make an impact as useful tools and reagents. Although many recently developed aptamers are intended for use as therapeutic and diagnostic agents, use of aptamers for basic research, including target validation, remains an active area with high potential to impact our understanding of molecular mechanisms and for drug discovery. In this brief review, we will discuss recent aptamer discoveries, their potential role in structural virology, as well as challenges and future prospects. |
format | Online Article Text |
id | pubmed-3274758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32747582012-02-16 Aptamers in Virology: Recent Advances and Challenges Binning, Jennifer M. Leung, Daisy W. Amarasinghe, Gaya K. Front Microbiol Microbiology Aptamers generated from randomized libraries of nucleic acids have found utility in a wide variety of fields and in the clinic. Aptamers can be used to target both intracellular and extracellular components, including small molecules, proteins, cells, and viruses. With recent technological developments in stringent selection and rapid isolation strategies, it is likely that aptamers will continue to make an impact as useful tools and reagents. Although many recently developed aptamers are intended for use as therapeutic and diagnostic agents, use of aptamers for basic research, including target validation, remains an active area with high potential to impact our understanding of molecular mechanisms and for drug discovery. In this brief review, we will discuss recent aptamer discoveries, their potential role in structural virology, as well as challenges and future prospects. Frontiers Research Foundation 2012-02-08 /pmc/articles/PMC3274758/ /pubmed/22347221 http://dx.doi.org/10.3389/fmicb.2012.00029 Text en Copyright © 2012 Binning, Leung and Amarasinghe. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
spellingShingle | Microbiology Binning, Jennifer M. Leung, Daisy W. Amarasinghe, Gaya K. Aptamers in Virology: Recent Advances and Challenges |
title | Aptamers in Virology: Recent Advances and Challenges |
title_full | Aptamers in Virology: Recent Advances and Challenges |
title_fullStr | Aptamers in Virology: Recent Advances and Challenges |
title_full_unstemmed | Aptamers in Virology: Recent Advances and Challenges |
title_short | Aptamers in Virology: Recent Advances and Challenges |
title_sort | aptamers in virology: recent advances and challenges |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274758/ https://www.ncbi.nlm.nih.gov/pubmed/22347221 http://dx.doi.org/10.3389/fmicb.2012.00029 |
work_keys_str_mv | AT binningjenniferm aptamersinvirologyrecentadvancesandchallenges AT leungdaisyw aptamersinvirologyrecentadvancesandchallenges AT amarasinghegayak aptamersinvirologyrecentadvancesandchallenges |