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(3R,4R,4aS,7aR,12bS)-3-Cyclopropylmethyl-4a,9-dihydroxy-3-methyl-7-oxo-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium bromide

The title compound, C(21)H(26)NO(4) (+)·Br(−), also known as R-methylnaltrexone (MNTX) bromide, is a selective peripherally acting μ-opioid receptor antagonist with a oroxymorphone skeleton, synthesized by hydroxyl protection, N-methylation, deprotection and anion exchange of naltrexone. It compr...

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Detalles Bibliográficos
Autores principales:	Chen, Xiangfeng, Zong, Zaiwei, Du, Youguo, Li, Jianguo, Sun, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2012
Materias:	Organic Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275079/ https://www.ncbi.nlm.nih.gov/pubmed/22347024 http://dx.doi.org/10.1107/S1600536812000645

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