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Genotype analysis of the human endostatin variant p.D104N in benign and malignant adrenocortical tumors

OBJECTIVE: Endostatin is a potent endogenous inhibitor of angiogenesis. It is derived from the proteolytic cleavage of collagen XVIII, which is encoded by the COL18A1 gene. A polymorphic COL18A1 allele encoding the functional polymorphism p.D104N impairs the activity of endostatin, resulting in a de...

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Detalles Bibliográficos
Autores principales:	de Paula Mariani, Beatriz Marinho, Trarbach, Ericka Barbosa, Ribeiro, Tamaya Castro, Pereira, Maria Adelaide Albergaria, Mendonca, Berenice Bilharinho, Fragoso, Maria Candida Barisson Villares
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2012
Materias:	Clinical Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275125/ https://www.ncbi.nlm.nih.gov/pubmed/22358232 http://dx.doi.org/10.6061/clinics/2012(02)02

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