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Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export

The NS1 protein of influenza virus is a major virulence factor essential for virus replication, as it redirects the host cell to promote viral protein expression. NS1 inhibits cellular messenger ribonucleic acid (mRNA) processing and export, down-regulating host gene expression and enhancing viral g...

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Detalles Bibliográficos
Autores principales:	Zhang, Liang, Das, Priyabrata, Schmolke, Mirco, Manicassamy, Balaji, Wang, Yaming, Deng, Xiaoyi, Cai, Ling, Tu, Benjamin P., Forst, Christian V., Roth, Michael G., Levy, David E., García-Sastre, Adolfo, de Brabander, Jef, Phillips, Margaret A., Fontoura, Beatriz M.A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275370/ https://www.ncbi.nlm.nih.gov/pubmed/22312003 http://dx.doi.org/10.1083/jcb.201107058

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