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Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia
BACKGROUND: The synapse-associated protein 97 gene (SAP97) encodes a regulatory scaffold protein for the localization of L-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA) type glutamate receptors. We have recently demonstrated nominally signi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275478/ https://www.ncbi.nlm.nih.gov/pubmed/22225629 http://dx.doi.org/10.1186/1744-9081-8-2 |
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author | Uezato, Akihito Kimura-Sato, Junko Yamamoto, Naoki Iijima, Yoshimi Kunugi, Hiroshi Nishikawa, Toru |
author_facet | Uezato, Akihito Kimura-Sato, Junko Yamamoto, Naoki Iijima, Yoshimi Kunugi, Hiroshi Nishikawa, Toru |
author_sort | Uezato, Akihito |
collection | PubMed |
description | BACKGROUND: The synapse-associated protein 97 gene (SAP97) encodes a regulatory scaffold protein for the localization of L-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA) type glutamate receptors. We have recently demonstrated nominally significant associations between SAP97 gene and schizophrenia among Japanese males. The present study aimed to replicate these findings using an independent and larger sample. METHODS: We investigated seven SAP97 single nucleotide polymorphisms (SNPs) that displayed a significant association with schizophrenia in our preceding study in an independent Japanese population consisting of a total of 393 unrelated patients with schizophrenia (232 males and 161 females) and 393 unrelated control subjects (211 males and 182 females). RESULTS: The SNP rs9843659 showed a significant genotypic association with male patients in a recessive model (p = 0.037). The analysis of the combined data from the current and prior studies also demonstrated a significant association of this SNP (p = 0.0039). The meta-analysis for the allele frequency covering the two studies yielded an odds ratio of 1.38. CONCLUSIONS: The present study replicated the previously reported male-selective genetic association between the SAP97 polymorphism and schizophrenia. These findings further support the possible involvement of the SAP97 gene variation in the susceptibility to schizophrenia in males and in the genetic basis for sex differences in the disorder. |
format | Online Article Text |
id | pubmed-3275478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32754782012-02-09 Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia Uezato, Akihito Kimura-Sato, Junko Yamamoto, Naoki Iijima, Yoshimi Kunugi, Hiroshi Nishikawa, Toru Behav Brain Funct Research BACKGROUND: The synapse-associated protein 97 gene (SAP97) encodes a regulatory scaffold protein for the localization of L-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA) type glutamate receptors. We have recently demonstrated nominally significant associations between SAP97 gene and schizophrenia among Japanese males. The present study aimed to replicate these findings using an independent and larger sample. METHODS: We investigated seven SAP97 single nucleotide polymorphisms (SNPs) that displayed a significant association with schizophrenia in our preceding study in an independent Japanese population consisting of a total of 393 unrelated patients with schizophrenia (232 males and 161 females) and 393 unrelated control subjects (211 males and 182 females). RESULTS: The SNP rs9843659 showed a significant genotypic association with male patients in a recessive model (p = 0.037). The analysis of the combined data from the current and prior studies also demonstrated a significant association of this SNP (p = 0.0039). The meta-analysis for the allele frequency covering the two studies yielded an odds ratio of 1.38. CONCLUSIONS: The present study replicated the previously reported male-selective genetic association between the SAP97 polymorphism and schizophrenia. These findings further support the possible involvement of the SAP97 gene variation in the susceptibility to schizophrenia in males and in the genetic basis for sex differences in the disorder. BioMed Central 2012-01-06 /pmc/articles/PMC3275478/ /pubmed/22225629 http://dx.doi.org/10.1186/1744-9081-8-2 Text en Copyright ©2012 Uezato et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Uezato, Akihito Kimura-Sato, Junko Yamamoto, Naoki Iijima, Yoshimi Kunugi, Hiroshi Nishikawa, Toru Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia |
title | Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia |
title_full | Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia |
title_fullStr | Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia |
title_full_unstemmed | Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia |
title_short | Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia |
title_sort | further evidence for a male-selective genetic association of synapse-associated protein 97 (sap97) gene with schizophrenia |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275478/ https://www.ncbi.nlm.nih.gov/pubmed/22225629 http://dx.doi.org/10.1186/1744-9081-8-2 |
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