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The Transcription Factor C/EBP delta Has Anti-Apoptotic and Anti-Inflammatory Roles in Pancreatic Beta Cells

In the course of Type 1 diabetes pro-inflammatory cytokines (e.g., IL-1β, IFN-γ and TNF-α) produced by islet-infiltrating immune cells modify expression of key gene networks in β-cells, leading to local inflammation and β-cell apoptosis. Most known cytokine-induced transcription factors have pro-apo...

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Detalles Bibliográficos
Autores principales:	Moore, Fabrice, Santin, Izortze, Nogueira, Tatiane C., Gurzov, Esteban N., Marselli, Lorella, Marchetti, Piero, Eizirik, Decio L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275575/ https://www.ncbi.nlm.nih.gov/pubmed/22347430 http://dx.doi.org/10.1371/journal.pone.0031062

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