Cellular Growth Kinetics Distinguish a Cyclophilin Inhibitor from an HSP90 Inhibitor as a Selective Inhibitor of Hepatitis C Virus

During antiviral drug discovery, it is critical to distinguish molecules that selectively interrupt viral replication from those that reduce virus replication by adversely affecting host cell viability. In this report we investigate the selectivity of inhibitors of the host chaperone proteins cyclop...

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Detalles Bibliográficos
Autores principales: Beran, Rudolf K. F., Sharma, Ruchi, Corsa, Amoreena C., Tian, Yang, Golde, Justin, Lundgaard, Greta, Delaney, William E., Zhong, Weidong, Greenstein, Andrew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275588/
https://www.ncbi.nlm.nih.gov/pubmed/22347373
http://dx.doi.org/10.1371/journal.pone.0030286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275588/
https://www.ncbi.nlm.nih.gov/pubmed/22347373
http://dx.doi.org/10.1371/journal.pone.0030286

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