CKD-712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Inhibits the NF-κB Activation and Augments Akt Activation during TLR4 Signaling

Since CKD-712 has been developed as an anti-inflammatory agent, we examined the effect of CKD-712 during TLR4 signaling. Using HEK293 cells expressing TLR4, CKD-712 was pre-treated 1 hr before LPS stimulation. Activation of NF-κB was assessed by promoter assay. The activation of ERK, JNK, p38, IRF3...

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Detalles Bibliográficos
Autores principales: Lee, Jeonggi, Yang, Eun-Jeong, Shin, Jeon-Soo, Kim, Dal-Hyun, Lee, Sung-Sook, Choi, In-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2011
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275714/
https://www.ncbi.nlm.nih.gov/pubmed/22346785
http://dx.doi.org/10.4110/in.2011.11.6.420

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