Persistence of Pneumolysin in the Cerebrospinal Fluid of Patients With Pneumococcal Meningitis Is Associated With Mortality

Poor prognosis in Pneumococcal meningitis may be associated with high pneumolysin levels in cerebrospinal fluid (CSF). In patient samples we showed that pneumolysin levels in CSF remained high after 48 hours in nonsurvivors of meningitis compared with survivors. Selective antipneumolysin treatment m...

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Autores principales: Wall, Emma C., Gordon, Stephen B., Hussain, Samia, Goonetilleke, Upali R. S., Gritzfeld, Jenna, Scarborough, Matthew, Kadioglu, Aras
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275762/
https://www.ncbi.nlm.nih.gov/pubmed/22238165
http://dx.doi.org/10.1093/cid/cir926
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author Wall, Emma C.
Gordon, Stephen B.
Hussain, Samia
Goonetilleke, Upali R. S.
Gritzfeld, Jenna
Scarborough, Matthew
Kadioglu, Aras
author_facet Wall, Emma C.
Gordon, Stephen B.
Hussain, Samia
Goonetilleke, Upali R. S.
Gritzfeld, Jenna
Scarborough, Matthew
Kadioglu, Aras
author_sort Wall, Emma C.
collection PubMed
description Poor prognosis in Pneumococcal meningitis may be associated with high pneumolysin levels in cerebrospinal fluid (CSF). In patient samples we showed that pneumolysin levels in CSF remained high after 48 hours in nonsurvivors of meningitis compared with survivors. Selective antipneumolysin treatment may present a novel therapeutic option.
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spelling pubmed-32757622012-02-09 Persistence of Pneumolysin in the Cerebrospinal Fluid of Patients With Pneumococcal Meningitis Is Associated With Mortality Wall, Emma C. Gordon, Stephen B. Hussain, Samia Goonetilleke, Upali R. S. Gritzfeld, Jenna Scarborough, Matthew Kadioglu, Aras Clin Infect Dis Brief Reports Poor prognosis in Pneumococcal meningitis may be associated with high pneumolysin levels in cerebrospinal fluid (CSF). In patient samples we showed that pneumolysin levels in CSF remained high after 48 hours in nonsurvivors of meningitis compared with survivors. Selective antipneumolysin treatment may present a novel therapeutic option. Oxford University Press 2012-03-01 2012-01-11 /pmc/articles/PMC3275762/ /pubmed/22238165 http://dx.doi.org/10.1093/cid/cir926 Text en © The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please email:journals.permissions@oup.com. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Wall, Emma C.
Gordon, Stephen B.
Hussain, Samia
Goonetilleke, Upali R. S.
Gritzfeld, Jenna
Scarborough, Matthew
Kadioglu, Aras
Persistence of Pneumolysin in the Cerebrospinal Fluid of Patients With Pneumococcal Meningitis Is Associated With Mortality
title Persistence of Pneumolysin in the Cerebrospinal Fluid of Patients With Pneumococcal Meningitis Is Associated With Mortality
title_full Persistence of Pneumolysin in the Cerebrospinal Fluid of Patients With Pneumococcal Meningitis Is Associated With Mortality
title_fullStr Persistence of Pneumolysin in the Cerebrospinal Fluid of Patients With Pneumococcal Meningitis Is Associated With Mortality
title_full_unstemmed Persistence of Pneumolysin in the Cerebrospinal Fluid of Patients With Pneumococcal Meningitis Is Associated With Mortality
title_short Persistence of Pneumolysin in the Cerebrospinal Fluid of Patients With Pneumococcal Meningitis Is Associated With Mortality
title_sort persistence of pneumolysin in the cerebrospinal fluid of patients with pneumococcal meningitis is associated with mortality
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275762/
https://www.ncbi.nlm.nih.gov/pubmed/22238165
http://dx.doi.org/10.1093/cid/cir926
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