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Radiation techniques for acromegaly
Radiotherapy (RT) remains an effective treatment in patients with acromegaly refractory to medical and/or surgical interventions, with durable tumor control and biochemical remission; however, there are still concerns about delayed biochemical effect and potential late toxicity of radiation treatmen...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275813/ https://www.ncbi.nlm.nih.gov/pubmed/22136376 http://dx.doi.org/10.1186/1748-717X-6-167 |
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author | Minniti, Giuseppe Scaringi, Claudia Enrici, Riccardo Maurizi |
author_facet | Minniti, Giuseppe Scaringi, Claudia Enrici, Riccardo Maurizi |
author_sort | Minniti, Giuseppe |
collection | PubMed |
description | Radiotherapy (RT) remains an effective treatment in patients with acromegaly refractory to medical and/or surgical interventions, with durable tumor control and biochemical remission; however, there are still concerns about delayed biochemical effect and potential late toxicity of radiation treatment, especially high rates of hypopituitarism. Stereotactic radiotherapy has been developed as a more accurate technique of irradiation with more precise tumour localization and consequently a reduction in the volume of normal tissue, particularly the brain, irradiated to high radiation doses. Radiation can be delivered in a single fraction by stereotactic radiosurgery (SRS) or as fractionated stereotactic radiotherapy (FSRT) in which smaller doses are delivered over 5-6 weeks in 25-30 treatments. A review of the recent literature suggests that pituitary irradiation is an effective treatment for acromegaly. Stereotactic techniques for GH-secreting pituitary tumors are discussed with the aim to define the efficacy and potential adverse effects of each of these techniques. |
format | Online Article Text |
id | pubmed-3275813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32758132012-02-09 Radiation techniques for acromegaly Minniti, Giuseppe Scaringi, Claudia Enrici, Riccardo Maurizi Radiat Oncol Review Radiotherapy (RT) remains an effective treatment in patients with acromegaly refractory to medical and/or surgical interventions, with durable tumor control and biochemical remission; however, there are still concerns about delayed biochemical effect and potential late toxicity of radiation treatment, especially high rates of hypopituitarism. Stereotactic radiotherapy has been developed as a more accurate technique of irradiation with more precise tumour localization and consequently a reduction in the volume of normal tissue, particularly the brain, irradiated to high radiation doses. Radiation can be delivered in a single fraction by stereotactic radiosurgery (SRS) or as fractionated stereotactic radiotherapy (FSRT) in which smaller doses are delivered over 5-6 weeks in 25-30 treatments. A review of the recent literature suggests that pituitary irradiation is an effective treatment for acromegaly. Stereotactic techniques for GH-secreting pituitary tumors are discussed with the aim to define the efficacy and potential adverse effects of each of these techniques. BioMed Central 2011-12-02 /pmc/articles/PMC3275813/ /pubmed/22136376 http://dx.doi.org/10.1186/1748-717X-6-167 Text en Copyright ©2011 Minniti et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Minniti, Giuseppe Scaringi, Claudia Enrici, Riccardo Maurizi Radiation techniques for acromegaly |
title | Radiation techniques for acromegaly |
title_full | Radiation techniques for acromegaly |
title_fullStr | Radiation techniques for acromegaly |
title_full_unstemmed | Radiation techniques for acromegaly |
title_short | Radiation techniques for acromegaly |
title_sort | radiation techniques for acromegaly |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275813/ https://www.ncbi.nlm.nih.gov/pubmed/22136376 http://dx.doi.org/10.1186/1748-717X-6-167 |
work_keys_str_mv | AT minnitigiuseppe radiationtechniquesforacromegaly AT scaringiclaudia radiationtechniquesforacromegaly AT enriciriccardomaurizi radiationtechniquesforacromegaly |