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Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study
Background. The present paper described the biological characteristics and clinical behavior of young women in the cohort NORA study Patients and Methods. From 2000–2002, patients (N > 3500) were enrolled at 77 Italian hospitals. Women aged ≤50 years (N = 1013) were stratified into age groups (≤3...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275934/ https://www.ncbi.nlm.nih.gov/pubmed/22332011 http://dx.doi.org/10.4061/2011/534256 |
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author | Pronzato, P. Mustacchi, G. De Matteis, A. Di Costanzo, F. Rulli, E. Floriani, I. Cazzaniga, M. E. |
author_facet | Pronzato, P. Mustacchi, G. De Matteis, A. Di Costanzo, F. Rulli, E. Floriani, I. Cazzaniga, M. E. |
author_sort | Pronzato, P. |
collection | PubMed |
description | Background. The present paper described the biological characteristics and clinical behavior of young women in the cohort NORA study Patients and Methods. From 2000–2002, patients (N > 3500) were enrolled at 77 Italian hospitals. Women aged ≤50 years (N = 1013) were stratified into age groups (≤35, 36–40, 41–45, and 46–50 years). The relationship between age and patient characteristics, cancer presentation, and treatment was analyzed. Results. Younger women more frequently had tumors with ER/PgR-negative(χ (2) = 7.07; P = .008), HER2 amplification (χ (2) = 5.76; P = .01), and high (≥10%) Ki67 labelling index (χ (2) = 9.53; P = .002). Positive nodal status, large tumors, and elevated Ki67 all associated with the choice for chemotherapy followed by endocrine therapy in hormone receptor-positive patients (P < .0001). At univariate analysis, ER-ve status, chemotherapy and age resulted as the only statistically significant variables (HR = 2.02, P = .004, and >40 versus ≤40, P < .0001, resp.). At multivariate analysis, after adjustment for significant clinical and pathological factors, age remains a significant prognostic variable (HR = 0.93, P = .0021). Conclusion. This cohort study suggests that age per sè is an important prognostic factor. The restricted role of early diagnosis and the aggressive behavior of cancer in this population make necessary the application of targeted medical strategies crucial. |
format | Online Article Text |
id | pubmed-3275934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-32759342012-02-13 Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study Pronzato, P. Mustacchi, G. De Matteis, A. Di Costanzo, F. Rulli, E. Floriani, I. Cazzaniga, M. E. Int J Breast Cancer Research Article Background. The present paper described the biological characteristics and clinical behavior of young women in the cohort NORA study Patients and Methods. From 2000–2002, patients (N > 3500) were enrolled at 77 Italian hospitals. Women aged ≤50 years (N = 1013) were stratified into age groups (≤35, 36–40, 41–45, and 46–50 years). The relationship between age and patient characteristics, cancer presentation, and treatment was analyzed. Results. Younger women more frequently had tumors with ER/PgR-negative(χ (2) = 7.07; P = .008), HER2 amplification (χ (2) = 5.76; P = .01), and high (≥10%) Ki67 labelling index (χ (2) = 9.53; P = .002). Positive nodal status, large tumors, and elevated Ki67 all associated with the choice for chemotherapy followed by endocrine therapy in hormone receptor-positive patients (P < .0001). At univariate analysis, ER-ve status, chemotherapy and age resulted as the only statistically significant variables (HR = 2.02, P = .004, and >40 versus ≤40, P < .0001, resp.). At multivariate analysis, after adjustment for significant clinical and pathological factors, age remains a significant prognostic variable (HR = 0.93, P = .0021). Conclusion. This cohort study suggests that age per sè is an important prognostic factor. The restricted role of early diagnosis and the aggressive behavior of cancer in this population make necessary the application of targeted medical strategies crucial. SAGE-Hindawi Access to Research 2011 2010-10-04 /pmc/articles/PMC3275934/ /pubmed/22332011 http://dx.doi.org/10.4061/2011/534256 Text en Copyright © 2011 P. Pronzato et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Pronzato, P. Mustacchi, G. De Matteis, A. Di Costanzo, F. Rulli, E. Floriani, I. Cazzaniga, M. E. Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study |
title | Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study |
title_full | Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study |
title_fullStr | Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study |
title_full_unstemmed | Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study |
title_short | Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study |
title_sort | biological characteristics and medical treatment of breast cancer in young women—a featured population: results from the nora study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275934/ https://www.ncbi.nlm.nih.gov/pubmed/22332011 http://dx.doi.org/10.4061/2011/534256 |
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