Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria

[Image: see text] Here, we describe the discovery of a novel antimalarial agent using phenotypic screening of Plasmodium falciparum asexual blood-stage parasites. Screening a novel compound collection created using diversity-oriented synthesis (DOS) led to the initial hit. Structure–activity relatio...

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Detalles Bibliográficos
Autores principales: Heidebrecht, Richard W., Mulrooney, Carol, Austin, Christopher P., Barker, Robert H., Beaudoin, Jennifer A., Cheng, Ken Chih-Chien, Comer, Eamon, Dandapani, Sivaraman, Dick, Justin, Duvall, Jeremy R., Ekland, Eric H., Fidock, David A., Fitzgerald, Mark E., Foley, Michael, Guha, Rajarshi, Hinkson, Paul, Kramer, Martin, Lukens, Amanda K., Masi, Daniela, Marcaurelle, Lisa A., Su, Xin-Zhuan, Thomas, Craig J., Weïwer, Michel, Wiegand, Roger C., Wirth, Dyann, Xia, Menghang, Yuan, Jing, Zhao, Jinghua, Palmer, Michelle, Munoz, Benito, Schreiber, Stuart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276110/
https://www.ncbi.nlm.nih.gov/pubmed/22328964
http://dx.doi.org/10.1021/ml200244k

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