Amino Acid Substitutions in the Caenorhabditis elegans RNA Polymerase II Large Subunit AMA-1/RPB-1 that Result in α-Amanitin Resistance and/or Reduced Function

Mutations in the Caenorhabditis elegans RNA polymerase II AMA-1/RPB-1 subunit that cause α-amanitin resistance and/or developmental defects were isolated previously. We identified 12 of these mutations and mapped them onto the Saccharomyces cerevisiae RPB1 structure to provide insight into AMA-1 reg...

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Detalles Bibliográficos
Autores principales: Bowman, Elizabeth Anne, Riddle, Donald L., Kelly, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2011
Materias:
Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276164/
https://www.ncbi.nlm.nih.gov/pubmed/22384351
http://dx.doi.org/10.1534/g3.111.000968
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author Bowman, Elizabeth Anne
Riddle, Donald L.
Kelly, William
author_facet Bowman, Elizabeth Anne
Riddle, Donald L.
Kelly, William
author_sort Bowman, Elizabeth Anne
collection PubMed
description Mutations in the Caenorhabditis elegans RNA polymerase II AMA-1/RPB-1 subunit that cause α-amanitin resistance and/or developmental defects were isolated previously. We identified 12 of these mutations and mapped them onto the Saccharomyces cerevisiae RPB1 structure to provide insight into AMA-1 regions that are essential for development in a multicellular organism.
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spelling pubmed-32761642012-03-01 Amino Acid Substitutions in the Caenorhabditis elegans RNA Polymerase II Large Subunit AMA-1/RPB-1 that Result in α-Amanitin Resistance and/or Reduced Function Bowman, Elizabeth Anne Riddle, Donald L. Kelly, William G3 (Bethesda) Investigation Mutations in the Caenorhabditis elegans RNA polymerase II AMA-1/RPB-1 subunit that cause α-amanitin resistance and/or developmental defects were isolated previously. We identified 12 of these mutations and mapped them onto the Saccharomyces cerevisiae RPB1 structure to provide insight into AMA-1 regions that are essential for development in a multicellular organism. Genetics Society of America 2011-11-01 /pmc/articles/PMC3276164/ /pubmed/22384351 http://dx.doi.org/10.1534/g3.111.000968 Text en Copyright © 2011 Bowman et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Investigation
Bowman, Elizabeth Anne
Riddle, Donald L.
Kelly, William
Amino Acid Substitutions in the Caenorhabditis elegans RNA Polymerase II Large Subunit AMA-1/RPB-1 that Result in α-Amanitin Resistance and/or Reduced Function
title Amino Acid Substitutions in the Caenorhabditis elegans RNA Polymerase II Large Subunit AMA-1/RPB-1 that Result in α-Amanitin Resistance and/or Reduced Function
title_full Amino Acid Substitutions in the Caenorhabditis elegans RNA Polymerase II Large Subunit AMA-1/RPB-1 that Result in α-Amanitin Resistance and/or Reduced Function
title_fullStr Amino Acid Substitutions in the Caenorhabditis elegans RNA Polymerase II Large Subunit AMA-1/RPB-1 that Result in α-Amanitin Resistance and/or Reduced Function
title_full_unstemmed Amino Acid Substitutions in the Caenorhabditis elegans RNA Polymerase II Large Subunit AMA-1/RPB-1 that Result in α-Amanitin Resistance and/or Reduced Function
title_short Amino Acid Substitutions in the Caenorhabditis elegans RNA Polymerase II Large Subunit AMA-1/RPB-1 that Result in α-Amanitin Resistance and/or Reduced Function
title_sort amino acid substitutions in the caenorhabditis elegans rna polymerase ii large subunit ama-1/rpb-1 that result in α-amanitin resistance and/or reduced function
topic Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276164/
https://www.ncbi.nlm.nih.gov/pubmed/22384351
http://dx.doi.org/10.1534/g3.111.000968
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