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Multiplex Chromosomal Exome Sequencing Accelerates Identification of ENU-Induced Mutations in the Mouse

Forward genetic screens in Mus musculus have proved powerfully informative by revealing unsuspected mechanisms governing basic biological processes. This approach uses potent chemical mutagens, such as N-ethyl-N-nitrosourea (ENU), to randomly induce mutations in mice, which are then bred and phenoty...

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Detalles Bibliográficos
Autores principales:	Sun, Miao, Mondal, Kajari, Patel, Viren, Horner, Vanessa L., Long, Alyssa B., Cutler, David J., Caspary, Tamara, Zwick, Michael E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2012
Materias:	Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276189/ https://www.ncbi.nlm.nih.gov/pubmed/22384391 http://dx.doi.org/10.1534/g3.111.001669

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