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Genetic Analysis of Fibroblast Growth Factor Signaling in the Drosophila Eye
The development of eyes in Drosophila involves intricate epithelial reorganization events for accurate positioning of cells and proper formation and organization of ommatidial clusters. We demonstrate that Branchless (Bnl), the fibroblast growth factor ligand, regulates restructuring events in the e...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Genetics Society of America
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276192/ https://www.ncbi.nlm.nih.gov/pubmed/22384378 http://dx.doi.org/10.1534/g3.111.001495 |
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author | Mukherjee, T. Choi, I. Banerjee, Utpal |
author_facet | Mukherjee, T. Choi, I. Banerjee, Utpal |
author_sort | Mukherjee, T. |
collection | PubMed |
description | The development of eyes in Drosophila involves intricate epithelial reorganization events for accurate positioning of cells and proper formation and organization of ommatidial clusters. We demonstrate that Branchless (Bnl), the fibroblast growth factor ligand, regulates restructuring events in the eye disc primordium from as early as the emergence of clusters from a morphogenetic front to the cellular movements during pupal eye development. Breathless (Btl) functions as the fibroblast growth factor receptor to mediate Bnl signal, and together they regulate expression of DE-cadherin, Crumbs, and Actin. In addition, in the eye Bnl regulates the temporal onset and extent of retinal basal glial cell migration by activating Btl in the glia. We hypothesized that the Bnl functions in the eye are Hedgehog dependent and represent novel aspects of Bnl signaling not explored previously. |
format | Online Article Text |
id | pubmed-3276192 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Genetics Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-32761922012-03-01 Genetic Analysis of Fibroblast Growth Factor Signaling in the Drosophila Eye Mukherjee, T. Choi, I. Banerjee, Utpal G3 (Bethesda) Investigation The development of eyes in Drosophila involves intricate epithelial reorganization events for accurate positioning of cells and proper formation and organization of ommatidial clusters. We demonstrate that Branchless (Bnl), the fibroblast growth factor ligand, regulates restructuring events in the eye disc primordium from as early as the emergence of clusters from a morphogenetic front to the cellular movements during pupal eye development. Breathless (Btl) functions as the fibroblast growth factor receptor to mediate Bnl signal, and together they regulate expression of DE-cadherin, Crumbs, and Actin. In addition, in the eye Bnl regulates the temporal onset and extent of retinal basal glial cell migration by activating Btl in the glia. We hypothesized that the Bnl functions in the eye are Hedgehog dependent and represent novel aspects of Bnl signaling not explored previously. Genetics Society of America 2012-01-01 /pmc/articles/PMC3276192/ /pubmed/22384378 http://dx.doi.org/10.1534/g3.111.001495 Text en Copyright © 2012 Mukherjee et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Investigation Mukherjee, T. Choi, I. Banerjee, Utpal Genetic Analysis of Fibroblast Growth Factor Signaling in the Drosophila Eye |
title | Genetic Analysis of Fibroblast Growth Factor Signaling in the Drosophila Eye |
title_full | Genetic Analysis of Fibroblast Growth Factor Signaling in the Drosophila Eye |
title_fullStr | Genetic Analysis of Fibroblast Growth Factor Signaling in the Drosophila Eye |
title_full_unstemmed | Genetic Analysis of Fibroblast Growth Factor Signaling in the Drosophila Eye |
title_short | Genetic Analysis of Fibroblast Growth Factor Signaling in the Drosophila Eye |
title_sort | genetic analysis of fibroblast growth factor signaling in the drosophila eye |
topic | Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276192/ https://www.ncbi.nlm.nih.gov/pubmed/22384378 http://dx.doi.org/10.1534/g3.111.001495 |
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