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Exercise as a Potential Treatment for Drug Abuse: Evidence from Preclinical Studies

Epidemiological studies reveal that individuals who engage in regular aerobic exercise are less likely to use and abuse illicit drugs. Until recently, very few studies had examined the causal influences that mediate this relationship, and it was not clear whether exercise was effective at reducing s...

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Autores principales: Smith, Mark A., Lynch, Wendy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276339/
https://www.ncbi.nlm.nih.gov/pubmed/22347866
http://dx.doi.org/10.3389/fpsyt.2011.00082
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author Smith, Mark A.
Lynch, Wendy J.
author_facet Smith, Mark A.
Lynch, Wendy J.
author_sort Smith, Mark A.
collection PubMed
description Epidemiological studies reveal that individuals who engage in regular aerobic exercise are less likely to use and abuse illicit drugs. Until recently, very few studies had examined the causal influences that mediate this relationship, and it was not clear whether exercise was effective at reducing substance use and abuse. In the past few years, several preclinical studies have revealed that exercise reduces drug self-administration in laboratory animals. These studies have revealed that exercise produces protective effects in procedures designed to model different transitional phases that occur during the development of, and recover from, a substance use disorder (e.g., acquisition, maintenance, escalation, and relapse/reinstatement of drug use). Moreover, recent studies have revealed several behavioral and neurobiological consequences of exercise that may be responsible for its protective effects in these assays. Collectively, these studies have provided convincing evidence to support the development of exercise-based interventions to reduce compulsive patterns of drug intake in clinical and at-risk populations.
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spelling pubmed-32763392012-02-17 Exercise as a Potential Treatment for Drug Abuse: Evidence from Preclinical Studies Smith, Mark A. Lynch, Wendy J. Front Psychiatry Psychiatry Epidemiological studies reveal that individuals who engage in regular aerobic exercise are less likely to use and abuse illicit drugs. Until recently, very few studies had examined the causal influences that mediate this relationship, and it was not clear whether exercise was effective at reducing substance use and abuse. In the past few years, several preclinical studies have revealed that exercise reduces drug self-administration in laboratory animals. These studies have revealed that exercise produces protective effects in procedures designed to model different transitional phases that occur during the development of, and recover from, a substance use disorder (e.g., acquisition, maintenance, escalation, and relapse/reinstatement of drug use). Moreover, recent studies have revealed several behavioral and neurobiological consequences of exercise that may be responsible for its protective effects in these assays. Collectively, these studies have provided convincing evidence to support the development of exercise-based interventions to reduce compulsive patterns of drug intake in clinical and at-risk populations. Frontiers Research Foundation 2012-01-12 /pmc/articles/PMC3276339/ /pubmed/22347866 http://dx.doi.org/10.3389/fpsyt.2011.00082 Text en Copyright © 2012 Smith and Lynch. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Psychiatry
Smith, Mark A.
Lynch, Wendy J.
Exercise as a Potential Treatment for Drug Abuse: Evidence from Preclinical Studies
title Exercise as a Potential Treatment for Drug Abuse: Evidence from Preclinical Studies
title_full Exercise as a Potential Treatment for Drug Abuse: Evidence from Preclinical Studies
title_fullStr Exercise as a Potential Treatment for Drug Abuse: Evidence from Preclinical Studies
title_full_unstemmed Exercise as a Potential Treatment for Drug Abuse: Evidence from Preclinical Studies
title_short Exercise as a Potential Treatment for Drug Abuse: Evidence from Preclinical Studies
title_sort exercise as a potential treatment for drug abuse: evidence from preclinical studies
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276339/
https://www.ncbi.nlm.nih.gov/pubmed/22347866
http://dx.doi.org/10.3389/fpsyt.2011.00082
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