Cargando…
IGF-1 and IGF-Binding Proteins and Bone Mass, Geometry, and Strength: Relation to Metabolic Control in Adolescent Girls With Type 1 Diabetes
Children and adolescents with poorly controlled type 1 diabetes mellitus (T1DM) are at risk for decreased bone mass. Growth hormone (GH) and its mediator, IGF-1, promote skeletal growth. Recent observations have suggested that children and adolescents with T1DM are at risk for decreased bone mineral...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR)
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276345/ https://www.ncbi.nlm.nih.gov/pubmed/18665784 http://dx.doi.org/10.1359/jbmr.080713 |
_version_ | 1782223356701966336 |
---|---|
author | Moyer-Mileur, Laurie J Slater, Hillarie Jordan, Kristine C Murray, Mary A |
author_facet | Moyer-Mileur, Laurie J Slater, Hillarie Jordan, Kristine C Murray, Mary A |
author_sort | Moyer-Mileur, Laurie J |
collection | PubMed |
description | Children and adolescents with poorly controlled type 1 diabetes mellitus (T1DM) are at risk for decreased bone mass. Growth hormone (GH) and its mediator, IGF-1, promote skeletal growth. Recent observations have suggested that children and adolescents with T1DM are at risk for decreased bone mineral acquisition. We examined the relationships between metabolic control, IGF-1 and its binding proteins (IGFBP-1, -3, -5), and bone mass in T1DM in adolescent girls 12–15 yr of age with T1DM (n = 11) and matched controls (n = 10). Subjects were admitted overnight and given a standardized diet. Periodic blood samples were obtained, and bone measurements were performed. Serum GH, IGFBP-1 and -5, glycosylated hemoglobin (HbA(1c)), glucose, and urine magnesium levels were higher and IGF-1 values were lower in T1DM compared with controls (p < 0.05). Whole body BMC/bone area (BA), femoral neck areal BMD (aBMD) and bone mineral apparent density (BMAD), and tibia cortical BMC were lower in T1DM (p < 0.05). Poor diabetes control predicted lower IGF-1 (r(2) = 0.21) and greater IGFBP-1 (r(2) = 0.39), IGFBP-5 (r(2) = 0.38), and bone-specific alkaline phosphatase (BALP; r(2) = 0.41, p < 0.05). Higher urine magnesium excretion predicted an overall shorter, lighter skeleton, and lower tibia cortical bone size, mineral, and density (r(2) = 0.44–0.75, p < 0.05). In the T1DM cohort, earlier age at diagnosis was predictive of lower IGF-1, higher urine magnesium excretion, and lighter, thinner cortical bone (r(2) ≥ 0.45, p < 0.01). We conclude that poor metabolic control alters the GH/IGF-1 axis, whereas greater urine magnesium excretion may reflect subtle changes in renal function and/or glucosuria leading to altered bone size and density in adolescent girls with T1DM. |
format | Online Article Text |
id | pubmed-3276345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) |
record_format | MEDLINE/PubMed |
spelling | pubmed-32763452012-02-13 IGF-1 and IGF-Binding Proteins and Bone Mass, Geometry, and Strength: Relation to Metabolic Control in Adolescent Girls With Type 1 Diabetes Moyer-Mileur, Laurie J Slater, Hillarie Jordan, Kristine C Murray, Mary A J Bone Miner Res Research-Articles Children and adolescents with poorly controlled type 1 diabetes mellitus (T1DM) are at risk for decreased bone mass. Growth hormone (GH) and its mediator, IGF-1, promote skeletal growth. Recent observations have suggested that children and adolescents with T1DM are at risk for decreased bone mineral acquisition. We examined the relationships between metabolic control, IGF-1 and its binding proteins (IGFBP-1, -3, -5), and bone mass in T1DM in adolescent girls 12–15 yr of age with T1DM (n = 11) and matched controls (n = 10). Subjects were admitted overnight and given a standardized diet. Periodic blood samples were obtained, and bone measurements were performed. Serum GH, IGFBP-1 and -5, glycosylated hemoglobin (HbA(1c)), glucose, and urine magnesium levels were higher and IGF-1 values were lower in T1DM compared with controls (p < 0.05). Whole body BMC/bone area (BA), femoral neck areal BMD (aBMD) and bone mineral apparent density (BMAD), and tibia cortical BMC were lower in T1DM (p < 0.05). Poor diabetes control predicted lower IGF-1 (r(2) = 0.21) and greater IGFBP-1 (r(2) = 0.39), IGFBP-5 (r(2) = 0.38), and bone-specific alkaline phosphatase (BALP; r(2) = 0.41, p < 0.05). Higher urine magnesium excretion predicted an overall shorter, lighter skeleton, and lower tibia cortical bone size, mineral, and density (r(2) = 0.44–0.75, p < 0.05). In the T1DM cohort, earlier age at diagnosis was predictive of lower IGF-1, higher urine magnesium excretion, and lighter, thinner cortical bone (r(2) ≥ 0.45, p < 0.01). We conclude that poor metabolic control alters the GH/IGF-1 axis, whereas greater urine magnesium excretion may reflect subtle changes in renal function and/or glucosuria leading to altered bone size and density in adolescent girls with T1DM. John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) 2008-12 2008-07-28 /pmc/articles/PMC3276345/ /pubmed/18665784 http://dx.doi.org/10.1359/jbmr.080713 Text en Copyright © 2008 American Society for Bone and Mineral Research http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Research-Articles Moyer-Mileur, Laurie J Slater, Hillarie Jordan, Kristine C Murray, Mary A IGF-1 and IGF-Binding Proteins and Bone Mass, Geometry, and Strength: Relation to Metabolic Control in Adolescent Girls With Type 1 Diabetes |
title | IGF-1 and IGF-Binding Proteins and Bone Mass, Geometry, and Strength: Relation to Metabolic Control in Adolescent Girls With Type 1 Diabetes |
title_full | IGF-1 and IGF-Binding Proteins and Bone Mass, Geometry, and Strength: Relation to Metabolic Control in Adolescent Girls With Type 1 Diabetes |
title_fullStr | IGF-1 and IGF-Binding Proteins and Bone Mass, Geometry, and Strength: Relation to Metabolic Control in Adolescent Girls With Type 1 Diabetes |
title_full_unstemmed | IGF-1 and IGF-Binding Proteins and Bone Mass, Geometry, and Strength: Relation to Metabolic Control in Adolescent Girls With Type 1 Diabetes |
title_short | IGF-1 and IGF-Binding Proteins and Bone Mass, Geometry, and Strength: Relation to Metabolic Control in Adolescent Girls With Type 1 Diabetes |
title_sort | igf-1 and igf-binding proteins and bone mass, geometry, and strength: relation to metabolic control in adolescent girls with type 1 diabetes |
topic | Research-Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276345/ https://www.ncbi.nlm.nih.gov/pubmed/18665784 http://dx.doi.org/10.1359/jbmr.080713 |
work_keys_str_mv | AT moyermileurlauriej igf1andigfbindingproteinsandbonemassgeometryandstrengthrelationtometaboliccontrolinadolescentgirlswithtype1diabetes AT slaterhillarie igf1andigfbindingproteinsandbonemassgeometryandstrengthrelationtometaboliccontrolinadolescentgirlswithtype1diabetes AT jordankristinec igf1andigfbindingproteinsandbonemassgeometryandstrengthrelationtometaboliccontrolinadolescentgirlswithtype1diabetes AT murraymarya igf1andigfbindingproteinsandbonemassgeometryandstrengthrelationtometaboliccontrolinadolescentgirlswithtype1diabetes |