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Metabolic Acidosis Increases Intracellular Calcium in Bone Cells Through Activation of the Proton Receptor OGR1

Metabolic acidosis increases urine Ca without increasing intestinal absorption, leading to bone Ca loss. It is unclear how bone cells detect the increase in proton concentration. To determine which G protein-coupled proton sensing receptors are expressed in bone, PCR was performed, and products were...

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Detalles Bibliográficos
Autores principales:	Frick, Kevin K, Krieger, Nancy S, Nehrke, Keith, Bushinsky, David A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) 2009
Materias:	Research-Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276358/ https://www.ncbi.nlm.nih.gov/pubmed/18847331 http://dx.doi.org/10.1359/jbmr.081015

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