Lithium Treatment of APPSwDI/NOS2−/− Mice Leads to Reduced Hyperphosphorylated Tau, Increased Amyloid Deposition and Altered Inflammatory Phenotype

Lithium is an anti-psychotic that has been shown to prevent the hyperphosphorylation of tau protein through the inhibition of glycogen-synthase kinase 3-beta (GSK3β). We recently developed a mouse model that progresses from amyloid pathology to tau pathology and neurodegeneration due to the genetic...

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Detalles Bibliográficos
Autores principales: Sudduth, Tiffany L., Wilson, Joan G., Everhart, Angela, Colton, Carol A., Wilcock, Donna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276493/
https://www.ncbi.nlm.nih.gov/pubmed/22347510
http://dx.doi.org/10.1371/journal.pone.0031993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276493/
https://www.ncbi.nlm.nih.gov/pubmed/22347510
http://dx.doi.org/10.1371/journal.pone.0031993

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