Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human Polymorphonuclear Leukocytes

BACKGROUND: 5-lipoxygenase (5-LO) catalyses the transformation of arachidonic acid (AA) into leukotrienes (LTs), which are important lipid mediators of inflammation. LTs have been directly implicated in inflammatory diseases like asthma, atherosclerosis and rheumatoid arthritis; therefore inhibition...

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Detalles Bibliográficos
Autores principales: Boudreau, Luc H., Maillet, Jacques, LeBlanc, Luc M., Jean-François, Jacques, Touaibia, Mohamed, Flamand, Nicolas, Surette, Marc E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276500/
https://www.ncbi.nlm.nih.gov/pubmed/22347509
http://dx.doi.org/10.1371/journal.pone.0031833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276500/
https://www.ncbi.nlm.nih.gov/pubmed/22347509
http://dx.doi.org/10.1371/journal.pone.0031833

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