Cargando…
Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1’s inhibitory effect on Bak
The intrinsic mitochondrial apoptotic pathway acts through two core pro-apoptotic proteins Bax and Bak. While Bax and Bak seem to play redundant roles in apoptosis, accumulating evidence also suggests that they might not be interchangeable under certain conditions, at least in some human cell lines....
Autores principales: | Wang, Chunxin, Youle, Richard J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276724/ https://www.ncbi.nlm.nih.gov/pubmed/22056880 http://dx.doi.org/10.1038/onc.2011.497 |
Ejemplares similares
-
Bak instead of Bax plays a key role in metformin-induced apoptosis s in HCT116 cells
por: Chen, Hongce, et al.
Publicado: (2021) -
MCL-1ES Induces MCL-1L-Dependent BAX- and BAK-Independent Mitochondrial Apoptosis
por: Kim, Jae-Hong, et al.
Publicado: (2013) -
Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis
por: Nechushtan, Amotz, et al.
Publicado: (2001) -
Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target
por: Iyer, Sweta, et al.
Publicado: (2020) -
The great migration of Bax and Bak
por: Edlich, Frank
Publicado: (2015)