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Morphine metabolism, transport and brain disposition

The chemical structures of morphine and its metabolites are closely related to the clinical effects of drugs (analgesia and side-effects) and to their capability to cross the Blood Brain Barrier (BBB). Morphine-6-glucuronide (M6G) and Morphine-3-glucuronide (M3G) are both highly hydrophilic, but onl...

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Detalles Bibliográficos
Autores principales: De Gregori, Simona, De Gregori, Manuela, Ranzani, Guglielmina Nadia, Allegri, Massimo, Minella, Cristina, Regazzi, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276770/
https://www.ncbi.nlm.nih.gov/pubmed/22193538
http://dx.doi.org/10.1007/s11011-011-9274-6