A Case of Cicatricial Alopecia Associated with Erlotinib

Erlotinib is a small-molecule tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR). Erlotinib has been used primarily to treat non-small cell lung cancer. In addition to its role in tumor cells, EGFR is also an important regulator of growth and differentiation in the skin a...

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Autores principales: Yang, Bo Hee, Bang, Chan Yl, Byun, Ji Won, Han, Sung Hyub, Song, Hee Jin, In, Seung Gyun, Shin, Jeong Hyun, Choi, Gwang Seong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Dermatological Association; The Korean Society for Investigative Dermatology 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276795/
https://www.ncbi.nlm.nih.gov/pubmed/22346276
http://dx.doi.org/10.5021/ad.2011.23.S3.S350
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author Yang, Bo Hee
Bang, Chan Yl
Byun, Ji Won
Han, Sung Hyub
Song, Hee Jin
In, Seung Gyun
Shin, Jeong Hyun
Choi, Gwang Seong
author_facet Yang, Bo Hee
Bang, Chan Yl
Byun, Ji Won
Han, Sung Hyub
Song, Hee Jin
In, Seung Gyun
Shin, Jeong Hyun
Choi, Gwang Seong
author_sort Yang, Bo Hee
collection PubMed
description Erlotinib is a small-molecule tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR). Erlotinib has been used primarily to treat non-small cell lung cancer. In addition to its role in tumor cells, EGFR is also an important regulator of growth and differentiation in the skin and hair. Therefore, EGFR-TKIs have been associated with a number of cutaneous side effects including follicular acneiform eruptions, cutaneous xerosis, chronic paronychia, desquamation, seborrheic dermatitis, and hair texture changes. Herein, we report a rare case of a 61-year-old woman who was treated with erlotinib and experienced cicatricial alopecia.
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spelling pubmed-32767952012-02-16 A Case of Cicatricial Alopecia Associated with Erlotinib Yang, Bo Hee Bang, Chan Yl Byun, Ji Won Han, Sung Hyub Song, Hee Jin In, Seung Gyun Shin, Jeong Hyun Choi, Gwang Seong Ann Dermatol Case Report Erlotinib is a small-molecule tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR). Erlotinib has been used primarily to treat non-small cell lung cancer. In addition to its role in tumor cells, EGFR is also an important regulator of growth and differentiation in the skin and hair. Therefore, EGFR-TKIs have been associated with a number of cutaneous side effects including follicular acneiform eruptions, cutaneous xerosis, chronic paronychia, desquamation, seborrheic dermatitis, and hair texture changes. Herein, we report a rare case of a 61-year-old woman who was treated with erlotinib and experienced cicatricial alopecia. Korean Dermatological Association; The Korean Society for Investigative Dermatology 2011-12 2011-12-27 /pmc/articles/PMC3276795/ /pubmed/22346276 http://dx.doi.org/10.5021/ad.2011.23.S3.S350 Text en Copyright © 2011 Korean Dermatological Association; The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Yang, Bo Hee
Bang, Chan Yl
Byun, Ji Won
Han, Sung Hyub
Song, Hee Jin
In, Seung Gyun
Shin, Jeong Hyun
Choi, Gwang Seong
A Case of Cicatricial Alopecia Associated with Erlotinib
title A Case of Cicatricial Alopecia Associated with Erlotinib
title_full A Case of Cicatricial Alopecia Associated with Erlotinib
title_fullStr A Case of Cicatricial Alopecia Associated with Erlotinib
title_full_unstemmed A Case of Cicatricial Alopecia Associated with Erlotinib
title_short A Case of Cicatricial Alopecia Associated with Erlotinib
title_sort case of cicatricial alopecia associated with erlotinib
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276795/
https://www.ncbi.nlm.nih.gov/pubmed/22346276
http://dx.doi.org/10.5021/ad.2011.23.S3.S350
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