Toxic Epidermal Necrolysis Associated with Sorafenib and Tosufloxacin in a Patient with Hepatocellular Carcinoma

This is the first case report to describe a 44-year-old woman with a history of advanced hepatocellular carcinoma who developed toxic epidermal necrolysis (TEN) clinically after taking 400 mg sorafenib (Nexavar®, BAY 43-9006) and tosufloxacin orally once per day. Both sorafenib and tosufloxacin were...

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Autores principales: Choi, Mun Ki, Woo, Hyun Young, Heo, Jeong, Cho, Mong, Kim, Gwang Ha, Song, Geun Am, Kim, Moon Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Dermatological Association; The Korean Society for Investigative Dermatology 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276809/
https://www.ncbi.nlm.nih.gov/pubmed/22346290
http://dx.doi.org/10.5021/ad.2011.23.S3.S404
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author Choi, Mun Ki
Woo, Hyun Young
Heo, Jeong
Cho, Mong
Kim, Gwang Ha
Song, Geun Am
Kim, Moon Bum
author_facet Choi, Mun Ki
Woo, Hyun Young
Heo, Jeong
Cho, Mong
Kim, Gwang Ha
Song, Geun Am
Kim, Moon Bum
author_sort Choi, Mun Ki
collection PubMed
description This is the first case report to describe a 44-year-old woman with a history of advanced hepatocellular carcinoma who developed toxic epidermal necrolysis (TEN) clinically after taking 400 mg sorafenib (Nexavar®, BAY 43-9006) and tosufloxacin orally once per day. Both sorafenib and tosufloxacin were eventually discontinued, and the TEN resolved with corticosteroids and supportive treatment. Clinical physicians should be aware of this possible complication so that early interventions can be made.
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spelling pubmed-32768092012-02-16 Toxic Epidermal Necrolysis Associated with Sorafenib and Tosufloxacin in a Patient with Hepatocellular Carcinoma Choi, Mun Ki Woo, Hyun Young Heo, Jeong Cho, Mong Kim, Gwang Ha Song, Geun Am Kim, Moon Bum Ann Dermatol Case Report This is the first case report to describe a 44-year-old woman with a history of advanced hepatocellular carcinoma who developed toxic epidermal necrolysis (TEN) clinically after taking 400 mg sorafenib (Nexavar®, BAY 43-9006) and tosufloxacin orally once per day. Both sorafenib and tosufloxacin were eventually discontinued, and the TEN resolved with corticosteroids and supportive treatment. Clinical physicians should be aware of this possible complication so that early interventions can be made. Korean Dermatological Association; The Korean Society for Investigative Dermatology 2011-12 2011-12-27 /pmc/articles/PMC3276809/ /pubmed/22346290 http://dx.doi.org/10.5021/ad.2011.23.S3.S404 Text en Copyright © 2011 Korean Dermatological Association; The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Choi, Mun Ki
Woo, Hyun Young
Heo, Jeong
Cho, Mong
Kim, Gwang Ha
Song, Geun Am
Kim, Moon Bum
Toxic Epidermal Necrolysis Associated with Sorafenib and Tosufloxacin in a Patient with Hepatocellular Carcinoma
title Toxic Epidermal Necrolysis Associated with Sorafenib and Tosufloxacin in a Patient with Hepatocellular Carcinoma
title_full Toxic Epidermal Necrolysis Associated with Sorafenib and Tosufloxacin in a Patient with Hepatocellular Carcinoma
title_fullStr Toxic Epidermal Necrolysis Associated with Sorafenib and Tosufloxacin in a Patient with Hepatocellular Carcinoma
title_full_unstemmed Toxic Epidermal Necrolysis Associated with Sorafenib and Tosufloxacin in a Patient with Hepatocellular Carcinoma
title_short Toxic Epidermal Necrolysis Associated with Sorafenib and Tosufloxacin in a Patient with Hepatocellular Carcinoma
title_sort toxic epidermal necrolysis associated with sorafenib and tosufloxacin in a patient with hepatocellular carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276809/
https://www.ncbi.nlm.nih.gov/pubmed/22346290
http://dx.doi.org/10.5021/ad.2011.23.S3.S404
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