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Dexmedetomidine Infusion to Facilitate Opioid Detoxification and Withdrawal in a Patient with Chronic Opioid Abuse

Many patients are admitted to the intensive care unit (ICU) for acute intoxication, serious complication of overdose, or withdrawal symptoms of illicit drugs. An acute withdrawal of drugs with addiction potential is associated with a sympathetic overactivity leading to marked psychomimetic disturban...

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Autores principales: Upadhyay, Surjya Prasad, Mallick, Piyush Narayan, Elmatite, Waleed Mohamed, Jagia, Manish, Taqi, Salah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276827/
https://www.ncbi.nlm.nih.gov/pubmed/22346054
http://dx.doi.org/10.4103/0973-1075.92353
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author Upadhyay, Surjya Prasad
Mallick, Piyush Narayan
Elmatite, Waleed Mohamed
Jagia, Manish
Taqi, Salah
author_facet Upadhyay, Surjya Prasad
Mallick, Piyush Narayan
Elmatite, Waleed Mohamed
Jagia, Manish
Taqi, Salah
author_sort Upadhyay, Surjya Prasad
collection PubMed
description Many patients are admitted to the intensive care unit (ICU) for acute intoxication, serious complication of overdose, or withdrawal symptoms of illicit drugs. An acute withdrawal of drugs with addiction potential is associated with a sympathetic overactivity leading to marked psychomimetic disturbances. Acute intoxication or withdrawal of such drugs is often associated with life-threatening complications which require ICU admission and necessitate prolonged sedative analgesic medications, weaning from which is often complicated by withdrawal and other psychomimetic symptoms. Dexmedetomidine, an alpha-2 (α(2)) agonist, has been used successfully to facilitate withdrawal and detoxification of various drugs and also to control delirium in ICU patients. Herein, we report a case of a chronic opioid abuse (heroin) patient admitted with acute overdose complications leading to a prolonged ICU course requiring sedative–analgesic medication; the drug withdrawal-related symptoms further complicated the weaning process. Dexmedetomidine infusion was successfully used as a sedative–analgesic to control the withdrawal-related psychomimetic symptoms and to facilitate smooth detoxification and weaning from opioid and other sedatives.
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spelling pubmed-32768272012-02-16 Dexmedetomidine Infusion to Facilitate Opioid Detoxification and Withdrawal in a Patient with Chronic Opioid Abuse Upadhyay, Surjya Prasad Mallick, Piyush Narayan Elmatite, Waleed Mohamed Jagia, Manish Taqi, Salah Indian J Palliat Care Case Report Many patients are admitted to the intensive care unit (ICU) for acute intoxication, serious complication of overdose, or withdrawal symptoms of illicit drugs. An acute withdrawal of drugs with addiction potential is associated with a sympathetic overactivity leading to marked psychomimetic disturbances. Acute intoxication or withdrawal of such drugs is often associated with life-threatening complications which require ICU admission and necessitate prolonged sedative analgesic medications, weaning from which is often complicated by withdrawal and other psychomimetic symptoms. Dexmedetomidine, an alpha-2 (α(2)) agonist, has been used successfully to facilitate withdrawal and detoxification of various drugs and also to control delirium in ICU patients. Herein, we report a case of a chronic opioid abuse (heroin) patient admitted with acute overdose complications leading to a prolonged ICU course requiring sedative–analgesic medication; the drug withdrawal-related symptoms further complicated the weaning process. Dexmedetomidine infusion was successfully used as a sedative–analgesic to control the withdrawal-related psychomimetic symptoms and to facilitate smooth detoxification and weaning from opioid and other sedatives. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3276827/ /pubmed/22346054 http://dx.doi.org/10.4103/0973-1075.92353 Text en Copyright: © Indian Journal of Palliative Care http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Upadhyay, Surjya Prasad
Mallick, Piyush Narayan
Elmatite, Waleed Mohamed
Jagia, Manish
Taqi, Salah
Dexmedetomidine Infusion to Facilitate Opioid Detoxification and Withdrawal in a Patient with Chronic Opioid Abuse
title Dexmedetomidine Infusion to Facilitate Opioid Detoxification and Withdrawal in a Patient with Chronic Opioid Abuse
title_full Dexmedetomidine Infusion to Facilitate Opioid Detoxification and Withdrawal in a Patient with Chronic Opioid Abuse
title_fullStr Dexmedetomidine Infusion to Facilitate Opioid Detoxification and Withdrawal in a Patient with Chronic Opioid Abuse
title_full_unstemmed Dexmedetomidine Infusion to Facilitate Opioid Detoxification and Withdrawal in a Patient with Chronic Opioid Abuse
title_short Dexmedetomidine Infusion to Facilitate Opioid Detoxification and Withdrawal in a Patient with Chronic Opioid Abuse
title_sort dexmedetomidine infusion to facilitate opioid detoxification and withdrawal in a patient with chronic opioid abuse
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276827/
https://www.ncbi.nlm.nih.gov/pubmed/22346054
http://dx.doi.org/10.4103/0973-1075.92353
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