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Monitoring tumor motion by real time 2D/3D registration during radiotherapy

BACKGROUND AND PURPOSE: In this paper, we investigate the possibility to use X-ray based real time 2D/3D registration for non-invasive tumor motion monitoring during radiotherapy. MATERIALS AND METHODS: The 2D/3D registration scheme is implemented using general purpose computation on graphics hardwa...

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Autores principales: Gendrin, Christelle, Furtado, Hugo, Weber, Christoph, Bloch, Christoph, Figl, Michael, Pawiro, Supriyanto Ardjo, Bergmann, Helmar, Stock, Markus, Fichtinger, Gabor, Georg, Dietmar, Birkfellner, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Scientific Publishers 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276833/
https://www.ncbi.nlm.nih.gov/pubmed/21885144
http://dx.doi.org/10.1016/j.radonc.2011.07.031
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author Gendrin, Christelle
Furtado, Hugo
Weber, Christoph
Bloch, Christoph
Figl, Michael
Pawiro, Supriyanto Ardjo
Bergmann, Helmar
Stock, Markus
Fichtinger, Gabor
Georg, Dietmar
Birkfellner, Wolfgang
author_facet Gendrin, Christelle
Furtado, Hugo
Weber, Christoph
Bloch, Christoph
Figl, Michael
Pawiro, Supriyanto Ardjo
Bergmann, Helmar
Stock, Markus
Fichtinger, Gabor
Georg, Dietmar
Birkfellner, Wolfgang
author_sort Gendrin, Christelle
collection PubMed
description BACKGROUND AND PURPOSE: In this paper, we investigate the possibility to use X-ray based real time 2D/3D registration for non-invasive tumor motion monitoring during radiotherapy. MATERIALS AND METHODS: The 2D/3D registration scheme is implemented using general purpose computation on graphics hardware (GPGPU) programming techniques and several algorithmic refinements in the registration process. Validation is conducted off-line using a phantom and five clinical patient data sets. The registration is performed on a region of interest (ROI) centered around the planned target volume (PTV). RESULTS: The phantom motion is measured with an rms error of 2.56 mm. For the patient data sets, a sinusoidal movement that clearly correlates to the breathing cycle is shown. Videos show a good match between X-ray and digitally reconstructed radiographs (DRR) displacement. Mean registration time is 0.5 s. CONCLUSIONS: We have demonstrated that real-time organ motion monitoring using image based markerless registration is feasible.
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spelling pubmed-32768332012-02-10 Monitoring tumor motion by real time 2D/3D registration during radiotherapy Gendrin, Christelle Furtado, Hugo Weber, Christoph Bloch, Christoph Figl, Michael Pawiro, Supriyanto Ardjo Bergmann, Helmar Stock, Markus Fichtinger, Gabor Georg, Dietmar Birkfellner, Wolfgang Radiother Oncol Organ Motion BACKGROUND AND PURPOSE: In this paper, we investigate the possibility to use X-ray based real time 2D/3D registration for non-invasive tumor motion monitoring during radiotherapy. MATERIALS AND METHODS: The 2D/3D registration scheme is implemented using general purpose computation on graphics hardware (GPGPU) programming techniques and several algorithmic refinements in the registration process. Validation is conducted off-line using a phantom and five clinical patient data sets. The registration is performed on a region of interest (ROI) centered around the planned target volume (PTV). RESULTS: The phantom motion is measured with an rms error of 2.56 mm. For the patient data sets, a sinusoidal movement that clearly correlates to the breathing cycle is shown. Videos show a good match between X-ray and digitally reconstructed radiographs (DRR) displacement. Mean registration time is 0.5 s. CONCLUSIONS: We have demonstrated that real-time organ motion monitoring using image based markerless registration is feasible. Elsevier Scientific Publishers 2012-02 /pmc/articles/PMC3276833/ /pubmed/21885144 http://dx.doi.org/10.1016/j.radonc.2011.07.031 Text en © 2012 Elsevier Ireland Ltd. https://creativecommons.org/licenses/by-nc-nd/3.0/ Open Access under CC BY-NC-ND 3.0 (https://creativecommons.org/licenses/by-nc-nd/3.0/) license
spellingShingle Organ Motion
Gendrin, Christelle
Furtado, Hugo
Weber, Christoph
Bloch, Christoph
Figl, Michael
Pawiro, Supriyanto Ardjo
Bergmann, Helmar
Stock, Markus
Fichtinger, Gabor
Georg, Dietmar
Birkfellner, Wolfgang
Monitoring tumor motion by real time 2D/3D registration during radiotherapy
title Monitoring tumor motion by real time 2D/3D registration during radiotherapy
title_full Monitoring tumor motion by real time 2D/3D registration during radiotherapy
title_fullStr Monitoring tumor motion by real time 2D/3D registration during radiotherapy
title_full_unstemmed Monitoring tumor motion by real time 2D/3D registration during radiotherapy
title_short Monitoring tumor motion by real time 2D/3D registration during radiotherapy
title_sort monitoring tumor motion by real time 2d/3d registration during radiotherapy
topic Organ Motion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276833/
https://www.ncbi.nlm.nih.gov/pubmed/21885144
http://dx.doi.org/10.1016/j.radonc.2011.07.031
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